Sin3a–Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency

Sin3a is a core component of histone-deacetylation-activity-associated transcriptional repressor complex, playing important roles in early embryo development. Here, we reported that down-regulation of Sin3a led to the loss of embryonic stem cell (ESC) self-renewal and skewed differentiation into mes...

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Detalles Bibliográficos
Autores principales: Zhu, Fugui, Zhu, Qianshu, Ye, Dan, Zhang, Qingquan, Yang, Yiwei, Guo, Xudong, Liu, Zhenping, Jiapaer, Zeyidan, Wan, Xiaoping, Wang, Guiying, Chen, Wen, Zhu, Songcheng, Jiang, Cizhong, Shi, Weiyang, Kang, Jiuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158608/
https://www.ncbi.nlm.nih.gov/pubmed/29733394
http://dx.doi.org/10.1093/nar/gky347

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