A DNA-sensing–independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-κB–mediated innate immunity against DNA virus infection

DExD/H-box helicase 9 (DHX9), or RNA helicase A (RHA), is an abundant multifunctional nuclear protein. Although it was previously reported to act as a cytosolic DNA sensor in plasmacytoid dendritic cells (pDCs), the role and molecular mechanisms of action of DHX9 in cells that are not pDCs during DN...

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Detalles Bibliográficos
Autores principales: Ng, Yee Ching, Chung, Woo-Chang, Kang, Hye-Ri, Cho, Hye-Jeong, Park, Eun-Byeol, Kang, Suk-Jo, Song, Moon Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158622/
https://www.ncbi.nlm.nih.gov/pubmed/30137501
http://dx.doi.org/10.1093/nar/gky742

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