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Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics

A disintegrin and metalloprotease (ADAM) family proteins are type-I transmembrane glycoproteins with multiple functions in cell adhesion, migration, proteolysis and signaling. ADAM10 is a member of the ADAM family reportedly involved in cancer progression and has been shown to be overexpressed in he...

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Autores principales: Shiu, Jr-Shiang, Hsieh, Ming-Ju, Chiou, Hui-Ling, Wang, Hsiang-Ling, Yeh, Chao-Bin, Yang, Shun-Fa, Chou, Ying-Erh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158669/
https://www.ncbi.nlm.nih.gov/pubmed/30275760
http://dx.doi.org/10.7150/ijms.27059
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author Shiu, Jr-Shiang
Hsieh, Ming-Ju
Chiou, Hui-Ling
Wang, Hsiang-Ling
Yeh, Chao-Bin
Yang, Shun-Fa
Chou, Ying-Erh
author_facet Shiu, Jr-Shiang
Hsieh, Ming-Ju
Chiou, Hui-Ling
Wang, Hsiang-Ling
Yeh, Chao-Bin
Yang, Shun-Fa
Chou, Ying-Erh
author_sort Shiu, Jr-Shiang
collection PubMed
description A disintegrin and metalloprotease (ADAM) family proteins are type-I transmembrane glycoproteins with multiple functions in cell adhesion, migration, proteolysis and signaling. ADAM10 is a member of the ADAM family reportedly involved in cancer progression and has been shown to be overexpressed in hepatocellular carcinoma (HCC) tissues and significantly associated with tumor progression and shortened survival. This study investigated ADAM10's single nucleotide polymorphisms (SNPs) and their association to HCC development and regulation. Real-time polymerase chain reaction was used to analyze five SNPs of ADAM10 in 333 patients with HCC and 1196 controls without cancer. The results indicated that of the 333 patients with HCC, those who carried ADAM10 rs514049 (AC + CC) variants had a higher risk of developing lymph node metastasis (odds ratio [OR] = 5.087, p = 0.027), and those who carried ADAM10 rs653765 (GA + AA) variants had a higher risk of developing distant metastasis (OR = 3.346, p = 0.020) and higher levels of α-fetoprotein. In conclusion, our study demonstrated that the SNPs of ADAM10 are involved in HCC progression. ADAM10 SNPs may be used as therapeutic targets to evaluate poor prognoses for HCC.
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spelling pubmed-61586692018-10-01 Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics Shiu, Jr-Shiang Hsieh, Ming-Ju Chiou, Hui-Ling Wang, Hsiang-Ling Yeh, Chao-Bin Yang, Shun-Fa Chou, Ying-Erh Int J Med Sci Research Paper A disintegrin and metalloprotease (ADAM) family proteins are type-I transmembrane glycoproteins with multiple functions in cell adhesion, migration, proteolysis and signaling. ADAM10 is a member of the ADAM family reportedly involved in cancer progression and has been shown to be overexpressed in hepatocellular carcinoma (HCC) tissues and significantly associated with tumor progression and shortened survival. This study investigated ADAM10's single nucleotide polymorphisms (SNPs) and their association to HCC development and regulation. Real-time polymerase chain reaction was used to analyze five SNPs of ADAM10 in 333 patients with HCC and 1196 controls without cancer. The results indicated that of the 333 patients with HCC, those who carried ADAM10 rs514049 (AC + CC) variants had a higher risk of developing lymph node metastasis (odds ratio [OR] = 5.087, p = 0.027), and those who carried ADAM10 rs653765 (GA + AA) variants had a higher risk of developing distant metastasis (OR = 3.346, p = 0.020) and higher levels of α-fetoprotein. In conclusion, our study demonstrated that the SNPs of ADAM10 are involved in HCC progression. ADAM10 SNPs may be used as therapeutic targets to evaluate poor prognoses for HCC. Ivyspring International Publisher 2018-08-10 /pmc/articles/PMC6158669/ /pubmed/30275760 http://dx.doi.org/10.7150/ijms.27059 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Shiu, Jr-Shiang
Hsieh, Ming-Ju
Chiou, Hui-Ling
Wang, Hsiang-Ling
Yeh, Chao-Bin
Yang, Shun-Fa
Chou, Ying-Erh
Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics
title Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics
title_full Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics
title_fullStr Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics
title_full_unstemmed Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics
title_short Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics
title_sort impact of adam10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158669/
https://www.ncbi.nlm.nih.gov/pubmed/30275760
http://dx.doi.org/10.7150/ijms.27059
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