CHD3 and CHD4 recruitment and chromatin remodeling activity at DNA breaks is promoted by early poly(ADP-ribose)-dependent chromatin relaxation

One of the first events to occur upon DNA damage is the local opening of the compact chromatin architecture, facilitating access of repair proteins to DNA lesions. This early relaxation is triggered by poly(ADP-ribosyl)ation by PARP1 in addition to ATP-dependent chromatin remodeling. CHD4 recruits t...

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Detalles Bibliográficos
Autores principales: Smith, Rebecca, Sellou, Hafida, Chapuis, Catherine, Huet, Sébastien, Timinszky, Gyula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158744/
https://www.ncbi.nlm.nih.gov/pubmed/29733391
http://dx.doi.org/10.1093/nar/gky334

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