α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β(1–42)-stimulated murine astrocytes

BACKGROUND: Neuroinflammation has an essential impact on the pathogenesis and progression of Alzheimer’s disease (AD). Mostly mediated by microglia and astrocytes, inflammatory processes lead to degeneration of neuronal cells. The NLRP3-inflammasome (NOD-like receptor family, pyrin domain containing...

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Detalles Bibliográficos
Autores principales: Ebrahimi, Taraneh, Rust, Marcus, Kaiser, Sarah Nele, Slowik, Alexander, Beyer, Cordian, Koczulla, Andreas Rembert, Schulz, Jörg B., Habib, Pardes, Bach, Jan Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158809/
https://www.ncbi.nlm.nih.gov/pubmed/30261895
http://dx.doi.org/10.1186/s12974-018-1319-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158809/
https://www.ncbi.nlm.nih.gov/pubmed/30261895
http://dx.doi.org/10.1186/s12974-018-1319-x

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