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α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β(1–42)-stimulated murine astrocytes

BACKGROUND: Neuroinflammation has an essential impact on the pathogenesis and progression of Alzheimer’s disease (AD). Mostly mediated by microglia and astrocytes, inflammatory processes lead to degeneration of neuronal cells. The NLRP3-inflammasome (NOD-like receptor family, pyrin domain containing...

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Detalles Bibliográficos
Autores principales:	Ebrahimi, Taraneh, Rust, Marcus, Kaiser, Sarah Nele, Slowik, Alexander, Beyer, Cordian, Koczulla, Andreas Rembert, Schulz, Jörg B., Habib, Pardes, Bach, Jan Philipp
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158809/ https://www.ncbi.nlm.nih.gov/pubmed/30261895 http://dx.doi.org/10.1186/s12974-018-1319-x

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