Successful use of ofatumumab in two cases of early-onset juvenile SLE with thrombocytopenia caused by a mutation in protein kinase C δ

BACKGROUND: We previously described an endogamous Pakistani kindred in whom we identified a novel homozygous missense mutation in the PRKCD gene encoding for protein kinase C δ (PKCδ) as a cause of monogenic systemic lupus erythematosus (SLE). PKCδ has a role in the negative regulation of B cells. G...

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Detalles Bibliográficos
Autores principales: Lei, Linda, Muhammad, Sabina, Al-Obaidi, Muthana, Sebire, Neil, Cheng, Iek Leng, Eleftheriou, Despina, Brogan, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158832/
https://www.ncbi.nlm.nih.gov/pubmed/30257684
http://dx.doi.org/10.1186/s12969-018-0278-1

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