Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation

Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA) and antisense oligonucleotides, are promising therapeutic agents. However, their low membrane permeability and sensitivity to nucleases present challenges to in vivo delivery. Chemical modifications of the ON offer...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Yating, Zhao, Yarong, Zhao, Xiuting, Lee, Robert J., Teng, Lesheng, Zhou, Chenguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158866/
https://www.ncbi.nlm.nih.gov/pubmed/29027965
http://dx.doi.org/10.3390/molecules22101724
_version_ 1783358502769524736
author Sun, Yating
Zhao, Yarong
Zhao, Xiuting
Lee, Robert J.
Teng, Lesheng
Zhou, Chenguang
author_facet Sun, Yating
Zhao, Yarong
Zhao, Xiuting
Lee, Robert J.
Teng, Lesheng
Zhou, Chenguang
author_sort Sun, Yating
collection PubMed
description Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA) and antisense oligonucleotides, are promising therapeutic agents. However, their low membrane permeability and sensitivity to nucleases present challenges to in vivo delivery. Chemical modifications of the ON offer a potential solution to improve the stability and efficacy of ON drugs. Combined with nanoparticle encapsulation, delivery at the site of action and gene silencing activity of chemically modified ON drugs can be further enhanced. In the present review, several types of ON drugs, selection of chemical modification, and nanoparticle-based delivery systems to deliver these ON drugs are discussed.
format Online
Article
Text
id pubmed-6158866
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61588662018-11-13 Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation Sun, Yating Zhao, Yarong Zhao, Xiuting Lee, Robert J. Teng, Lesheng Zhou, Chenguang Molecules Review Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA) and antisense oligonucleotides, are promising therapeutic agents. However, their low membrane permeability and sensitivity to nucleases present challenges to in vivo delivery. Chemical modifications of the ON offer a potential solution to improve the stability and efficacy of ON drugs. Combined with nanoparticle encapsulation, delivery at the site of action and gene silencing activity of chemically modified ON drugs can be further enhanced. In the present review, several types of ON drugs, selection of chemical modification, and nanoparticle-based delivery systems to deliver these ON drugs are discussed. MDPI 2017-10-13 /pmc/articles/PMC6158866/ /pubmed/29027965 http://dx.doi.org/10.3390/molecules22101724 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sun, Yating
Zhao, Yarong
Zhao, Xiuting
Lee, Robert J.
Teng, Lesheng
Zhou, Chenguang
Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation
title Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation
title_full Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation
title_fullStr Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation
title_full_unstemmed Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation
title_short Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation
title_sort enhancing the therapeutic delivery of oligonucleotides by chemical modification and nanoparticle encapsulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158866/
https://www.ncbi.nlm.nih.gov/pubmed/29027965
http://dx.doi.org/10.3390/molecules22101724
work_keys_str_mv AT sunyating enhancingthetherapeuticdeliveryofoligonucleotidesbychemicalmodificationandnanoparticleencapsulation
AT zhaoyarong enhancingthetherapeuticdeliveryofoligonucleotidesbychemicalmodificationandnanoparticleencapsulation
AT zhaoxiuting enhancingthetherapeuticdeliveryofoligonucleotidesbychemicalmodificationandnanoparticleencapsulation
AT leerobertj enhancingthetherapeuticdeliveryofoligonucleotidesbychemicalmodificationandnanoparticleencapsulation
AT tenglesheng enhancingthetherapeuticdeliveryofoligonucleotidesbychemicalmodificationandnanoparticleencapsulation
AT zhouchenguang enhancingthetherapeuticdeliveryofoligonucleotidesbychemicalmodificationandnanoparticleencapsulation

Ejemplares similares