Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation

Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA) and antisense oligonucleotides, are promising therapeutic agents. However, their low membrane permeability and sensitivity to nucleases present challenges to in vivo delivery. Chemical modifications of the ON offer...

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Detalles Bibliográficos
Autores principales: Sun, Yating, Zhao, Yarong, Zhao, Xiuting, Lee, Robert J., Teng, Lesheng, Zhou, Chenguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158866/
https://www.ncbi.nlm.nih.gov/pubmed/29027965
http://dx.doi.org/10.3390/molecules22101724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158866/
https://www.ncbi.nlm.nih.gov/pubmed/29027965
http://dx.doi.org/10.3390/molecules22101724

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