Osteogenesis and aging: lessons from mesenchymal stem cells

Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related progressive disease characterized by reduced bone mass and increased risk of fractures. At the cellular level, the mesenchymal stem cell pool in the bone marrow niche shows a biased differentiation into adi...

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Detalles Bibliográficos
Autores principales: Infante, Arantza, Rodríguez, Clara I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158877/
https://www.ncbi.nlm.nih.gov/pubmed/30257716
http://dx.doi.org/10.1186/s13287-018-0995-x
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author Infante, Arantza
Rodríguez, Clara I.
author_facet Infante, Arantza
Rodríguez, Clara I.
author_sort Infante, Arantza
collection PubMed
description Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related progressive disease characterized by reduced bone mass and increased risk of fractures. At the cellular level, the mesenchymal stem cell pool in the bone marrow niche shows a biased differentiation into adipogenesis at the cost of osteogenesis. This differentiation shift leads to decreased bone formation, contributing to the etiology of osteoporosis. This review will focus on the most recent/relevant molecular findings driving this functional impairment of mesenchymal stem cells in the aging process.
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spelling pubmed-61588772018-10-01 Osteogenesis and aging: lessons from mesenchymal stem cells Infante, Arantza Rodríguez, Clara I. Stem Cell Res Ther Review Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related progressive disease characterized by reduced bone mass and increased risk of fractures. At the cellular level, the mesenchymal stem cell pool in the bone marrow niche shows a biased differentiation into adipogenesis at the cost of osteogenesis. This differentiation shift leads to decreased bone formation, contributing to the etiology of osteoporosis. This review will focus on the most recent/relevant molecular findings driving this functional impairment of mesenchymal stem cells in the aging process. BioMed Central 2018-09-26 /pmc/articles/PMC6158877/ /pubmed/30257716 http://dx.doi.org/10.1186/s13287-018-0995-x Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Infante, Arantza
Rodríguez, Clara I.
Osteogenesis and aging: lessons from mesenchymal stem cells
title Osteogenesis and aging: lessons from mesenchymal stem cells
title_full Osteogenesis and aging: lessons from mesenchymal stem cells
title_fullStr Osteogenesis and aging: lessons from mesenchymal stem cells
title_full_unstemmed Osteogenesis and aging: lessons from mesenchymal stem cells
title_short Osteogenesis and aging: lessons from mesenchymal stem cells
title_sort osteogenesis and aging: lessons from mesenchymal stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158877/
https://www.ncbi.nlm.nih.gov/pubmed/30257716
http://dx.doi.org/10.1186/s13287-018-0995-x
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