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Inner ear enhancement on gadolinium-enhanced 3D FLAIR images in a patient with Vogt–Koyanagi–Harada disease
Vogt–Koyanagi–Harada (VKH) disease is an autoimmune disorder that occurs in the melanocytes present in the uvea, leptomeninges, skin and inner ear. Clinically, this disease is characterized by bilateral uveitis and retinal detachment and is associated with meningismus and hearing loss. Gadolinium (G...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The British Institute of Radiology
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159301/ https://www.ncbi.nlm.nih.gov/pubmed/30363318 http://dx.doi.org/10.1259/bjrcr.20160090 |
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author | Hida, Kosuke Takano, Koichi Yoshimitsu, Kengo Fukae, Jiro Hokao, Koichi |
author_facet | Hida, Kosuke Takano, Koichi Yoshimitsu, Kengo Fukae, Jiro Hokao, Koichi |
author_sort | Hida, Kosuke |
collection | PubMed |
description | Vogt–Koyanagi–Harada (VKH) disease is an autoimmune disorder that occurs in the melanocytes present in the uvea, leptomeninges, skin and inner ear. Clinically, this disease is characterized by bilateral uveitis and retinal detachment and is associated with meningismus and hearing loss. Gadolinium (Gd)-enhanced MRI may aid in demonstrating bilateral choroidal thickening and central nervous system involvement. We present a case of VKH where Gd-enhanced three-dimensional (3D) fluid attenuation inversion recovery (FLAIR) imaging showed abnormal bilateral enhancement in the inner ears. A 36-year-old female was referred to our institution with symptoms of visual disturbance, headache and tinnitus, and was diagnosed with VKH based on fundus examination and clinical presentations. MRI findings revealed bilateral enhancement in the choroid, leptomeninges, and inner ears. In particular, Gd-enhanced 3D FLAIR showed more conspicuous enhancement of the leptomeninges and inner ear compared with Gd-enhanced 3D T(1) weighted image. Therefore, Gd-enhanced 3D FLAIR imaging can be used when leptomeningeal or inner ear pathology is clinically suspected. |
format | Online Article Text |
id | pubmed-6159301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The British Institute of Radiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-61593012018-10-25 Inner ear enhancement on gadolinium-enhanced 3D FLAIR images in a patient with Vogt–Koyanagi–Harada disease Hida, Kosuke Takano, Koichi Yoshimitsu, Kengo Fukae, Jiro Hokao, Koichi BJR Case Rep Case Report Vogt–Koyanagi–Harada (VKH) disease is an autoimmune disorder that occurs in the melanocytes present in the uvea, leptomeninges, skin and inner ear. Clinically, this disease is characterized by bilateral uveitis and retinal detachment and is associated with meningismus and hearing loss. Gadolinium (Gd)-enhanced MRI may aid in demonstrating bilateral choroidal thickening and central nervous system involvement. We present a case of VKH where Gd-enhanced three-dimensional (3D) fluid attenuation inversion recovery (FLAIR) imaging showed abnormal bilateral enhancement in the inner ears. A 36-year-old female was referred to our institution with symptoms of visual disturbance, headache and tinnitus, and was diagnosed with VKH based on fundus examination and clinical presentations. MRI findings revealed bilateral enhancement in the choroid, leptomeninges, and inner ears. In particular, Gd-enhanced 3D FLAIR showed more conspicuous enhancement of the leptomeninges and inner ear compared with Gd-enhanced 3D T(1) weighted image. Therefore, Gd-enhanced 3D FLAIR imaging can be used when leptomeningeal or inner ear pathology is clinically suspected. The British Institute of Radiology 2016-09-16 /pmc/articles/PMC6159301/ /pubmed/30363318 http://dx.doi.org/10.1259/bjrcr.20160090 Text en © 2017 The Authors. Published by the British Institute of Radiology http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Case Report Hida, Kosuke Takano, Koichi Yoshimitsu, Kengo Fukae, Jiro Hokao, Koichi Inner ear enhancement on gadolinium-enhanced 3D FLAIR images in a patient with Vogt–Koyanagi–Harada disease |
title | Inner ear enhancement on gadolinium-enhanced 3D FLAIR images in a patient with Vogt–Koyanagi–Harada disease |
title_full | Inner ear enhancement on gadolinium-enhanced 3D FLAIR images in a patient with Vogt–Koyanagi–Harada disease |
title_fullStr | Inner ear enhancement on gadolinium-enhanced 3D FLAIR images in a patient with Vogt–Koyanagi–Harada disease |
title_full_unstemmed | Inner ear enhancement on gadolinium-enhanced 3D FLAIR images in a patient with Vogt–Koyanagi–Harada disease |
title_short | Inner ear enhancement on gadolinium-enhanced 3D FLAIR images in a patient with Vogt–Koyanagi–Harada disease |
title_sort | inner ear enhancement on gadolinium-enhanced 3d flair images in a patient with vogt–koyanagi–harada disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159301/ https://www.ncbi.nlm.nih.gov/pubmed/30363318 http://dx.doi.org/10.1259/bjrcr.20160090 |
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