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Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy
The eukaryotic host is in close contact to myriads of resident and transient microbes, which influence the crucial physiological pathways. Emerging evidence points to their role of host–microbe interactions for controlling tissue homeostasis, cell fate decisions, and regenerative capacity in epithel...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159313/ https://www.ncbi.nlm.nih.gov/pubmed/30294304 http://dx.doi.org/10.3389/fmicb.2018.02020 |
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author | von Frieling, Jakob Fink, Christine Hamm, Jacob Klischies, Kenneth Forster, Michael Bosch, Thomas C. G. Roeder, Thomas Rosenstiel, Philip Sommer, Felix |
author_facet | von Frieling, Jakob Fink, Christine Hamm, Jacob Klischies, Kenneth Forster, Michael Bosch, Thomas C. G. Roeder, Thomas Rosenstiel, Philip Sommer, Felix |
author_sort | von Frieling, Jakob |
collection | PubMed |
description | The eukaryotic host is in close contact to myriads of resident and transient microbes, which influence the crucial physiological pathways. Emerging evidence points to their role of host–microbe interactions for controlling tissue homeostasis, cell fate decisions, and regenerative capacity in epithelial barrier organs including the skin, lung, and gut. In humans and mice, it has been shown that the malignant tumors of these organs harbor an altered microbiota. Mechanistic studies have shown that the altered metabolic properties and secreted factors contribute to epithelial carcinogenesis and tumor progression. Exciting recent work points toward a crucial influence of the associated microbial communities on the response to chemotherapy and immune-check point inhibitors during cancer treatment, which suggests that the modulation of the microbiota might be a powerful tool for personalized oncology. In this article, we provide an overview of how the bacterial signals and signatures may influence epithelial homeostasis across taxa from cnidarians to vertebrates and delineate mechanisms, which might be potential targets for therapy of human diseases by either harnessing barrier integrity (infection and inflammation) or restoring uncontrolled proliferation (cancer). |
format | Online Article Text |
id | pubmed-6159313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61593132018-10-05 Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy von Frieling, Jakob Fink, Christine Hamm, Jacob Klischies, Kenneth Forster, Michael Bosch, Thomas C. G. Roeder, Thomas Rosenstiel, Philip Sommer, Felix Front Microbiol Microbiology The eukaryotic host is in close contact to myriads of resident and transient microbes, which influence the crucial physiological pathways. Emerging evidence points to their role of host–microbe interactions for controlling tissue homeostasis, cell fate decisions, and regenerative capacity in epithelial barrier organs including the skin, lung, and gut. In humans and mice, it has been shown that the malignant tumors of these organs harbor an altered microbiota. Mechanistic studies have shown that the altered metabolic properties and secreted factors contribute to epithelial carcinogenesis and tumor progression. Exciting recent work points toward a crucial influence of the associated microbial communities on the response to chemotherapy and immune-check point inhibitors during cancer treatment, which suggests that the modulation of the microbiota might be a powerful tool for personalized oncology. In this article, we provide an overview of how the bacterial signals and signatures may influence epithelial homeostasis across taxa from cnidarians to vertebrates and delineate mechanisms, which might be potential targets for therapy of human diseases by either harnessing barrier integrity (infection and inflammation) or restoring uncontrolled proliferation (cancer). Frontiers Media S.A. 2018-09-20 /pmc/articles/PMC6159313/ /pubmed/30294304 http://dx.doi.org/10.3389/fmicb.2018.02020 Text en Copyright © 2018 von Frieling, Fink, Hamm, Klischies, Forster, Bosch, Roeder, Rosenstiel and Sommer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology von Frieling, Jakob Fink, Christine Hamm, Jacob Klischies, Kenneth Forster, Michael Bosch, Thomas C. G. Roeder, Thomas Rosenstiel, Philip Sommer, Felix Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy |
title | Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy |
title_full | Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy |
title_fullStr | Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy |
title_full_unstemmed | Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy |
title_short | Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy |
title_sort | grow with the challenge – microbial effects on epithelial proliferation, carcinogenesis, and cancer therapy |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159313/ https://www.ncbi.nlm.nih.gov/pubmed/30294304 http://dx.doi.org/10.3389/fmicb.2018.02020 |
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