Elongator subunit 3 (ELP3) modifies ALS through tRNA modification

Amyotrophic lateral sclerosis (ALS) is a fatal degenerative motor neuron disorder of which the progression is influenced by several disease-modifying factors. Here, we investigated ELP3, a subunit of the elongator complex that modifies tRNA wobble uridines, as one of such ALS disease modifiers. ELP3...

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Detalles Bibliográficos
Autores principales: Bento-Abreu, Andre, Jager, Gunilla, Swinnen, Bart, Rué, Laura, Hendrickx, Stijn, Jones, Ashley, Staats, Kim A, Taes, Ines, Eykens, Caroline, Nonneman, Annelies, Nuyts, Rik, Timmers, Mieke, Silva, Lara, Chariot, Alain, Nguyen, Laurent, Ravits, John, Lemmens, Robin, Cabooter, Deirdre, Van Den Bosch, Ludo, Van Damme, Philip, Al-Chalabi, Ammar, Bystrom, Anders, Robberecht, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159532/
https://www.ncbi.nlm.nih.gov/pubmed/29415125
http://dx.doi.org/10.1093/hmg/ddy043

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