Perfusion-Phase [(18)F]THK5351 Tau-PET Imaging as a Surrogate Marker for Neurodegeneration

We aimed to test if early, perfusion phase tau-PET imaging with [(18)F]THK5351 might substitute for [(18)F]FDG PET information on neurodegeneration, as has been previously shown for amyloid-tracers. A patient with cognitive impairment and positive amyloid-PET was examined by [(18)F]THK5351 tau-PET a...

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Autores principales: Brendel, Matthias, Wagner, Leonie, Levin, Johannes, Zach, Christian, Lindner, Simon, Bartenstein, Peter, Okamura, Nobuyuki, Rominger, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159627/
https://www.ncbi.nlm.nih.gov/pubmed/30480233
http://dx.doi.org/10.3233/ADR-170023
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author Brendel, Matthias
Wagner, Leonie
Levin, Johannes
Zach, Christian
Lindner, Simon
Bartenstein, Peter
Okamura, Nobuyuki
Rominger, Axel
author_facet Brendel, Matthias
Wagner, Leonie
Levin, Johannes
Zach, Christian
Lindner, Simon
Bartenstein, Peter
Okamura, Nobuyuki
Rominger, Axel
author_sort Brendel, Matthias
collection PubMed
description We aimed to test if early, perfusion phase tau-PET imaging with [(18)F]THK5351 might substitute for [(18)F]FDG PET information on neurodegeneration, as has been previously shown for amyloid-tracers. A patient with cognitive impairment and positive amyloid-PET was examined by [(18)F]THK5351 tau-PET and [(18)F]FDG PET. The pattern of early phase of [(18)F]THK5351 uptake was compared to [(18)F]FDG visually and by the dice similarity coefficient. Visual inspection of axial slices and stereotactic-surface projection indicated a striking agreement between combined 0–2 min p.i. perfusion images of [(18)F]THK5351 and standard [(18)F]FDG 30–60 min p.i. A two-phase protocol of [(18)F]THK5351 PET might give information on neurodegeneration and tau pathology in a single session.
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spelling pubmed-61596272018-11-26 Perfusion-Phase [(18)F]THK5351 Tau-PET Imaging as a Surrogate Marker for Neurodegeneration Brendel, Matthias Wagner, Leonie Levin, Johannes Zach, Christian Lindner, Simon Bartenstein, Peter Okamura, Nobuyuki Rominger, Axel J Alzheimers Dis Rep Research Article We aimed to test if early, perfusion phase tau-PET imaging with [(18)F]THK5351 might substitute for [(18)F]FDG PET information on neurodegeneration, as has been previously shown for amyloid-tracers. A patient with cognitive impairment and positive amyloid-PET was examined by [(18)F]THK5351 tau-PET and [(18)F]FDG PET. The pattern of early phase of [(18)F]THK5351 uptake was compared to [(18)F]FDG visually and by the dice similarity coefficient. Visual inspection of axial slices and stereotactic-surface projection indicated a striking agreement between combined 0–2 min p.i. perfusion images of [(18)F]THK5351 and standard [(18)F]FDG 30–60 min p.i. A two-phase protocol of [(18)F]THK5351 PET might give information on neurodegeneration and tau pathology in a single session. IOS Press 2017-09-28 /pmc/articles/PMC6159627/ /pubmed/30480233 http://dx.doi.org/10.3233/ADR-170023 Text en © 2017 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Brendel, Matthias
Wagner, Leonie
Levin, Johannes
Zach, Christian
Lindner, Simon
Bartenstein, Peter
Okamura, Nobuyuki
Rominger, Axel
Perfusion-Phase [(18)F]THK5351 Tau-PET Imaging as a Surrogate Marker for Neurodegeneration
title Perfusion-Phase [(18)F]THK5351 Tau-PET Imaging as a Surrogate Marker for Neurodegeneration
title_full Perfusion-Phase [(18)F]THK5351 Tau-PET Imaging as a Surrogate Marker for Neurodegeneration
title_fullStr Perfusion-Phase [(18)F]THK5351 Tau-PET Imaging as a Surrogate Marker for Neurodegeneration
title_full_unstemmed Perfusion-Phase [(18)F]THK5351 Tau-PET Imaging as a Surrogate Marker for Neurodegeneration
title_short Perfusion-Phase [(18)F]THK5351 Tau-PET Imaging as a Surrogate Marker for Neurodegeneration
title_sort perfusion-phase [(18)f]thk5351 tau-pet imaging as a surrogate marker for neurodegeneration
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159627/
https://www.ncbi.nlm.nih.gov/pubmed/30480233
http://dx.doi.org/10.3233/ADR-170023
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