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Overview and Current Status of Alzheimer’s Disease in Bangladesh

Alzheimer’s disease (AD) is a complex neurological disorder with economic, social, and medical burdens which is acknowledged as leading cause of dementia marked by the accumulation and aggregation of amyloid-β peptide and phosphorylated tau (p-tau) protein and concomitant dementia, neuron loss and b...

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Autores principales: Rahman, Md. Rashidur, Tajmim, Afsana, Ali, Mohammad, Sharif, Mostakim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159651/
https://www.ncbi.nlm.nih.gov/pubmed/30480227
http://dx.doi.org/10.3233/ADR-170012
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author Rahman, Md. Rashidur
Tajmim, Afsana
Ali, Mohammad
Sharif, Mostakim
author_facet Rahman, Md. Rashidur
Tajmim, Afsana
Ali, Mohammad
Sharif, Mostakim
author_sort Rahman, Md. Rashidur
collection PubMed
description Alzheimer’s disease (AD) is a complex neurological disorder with economic, social, and medical burdens which is acknowledged as leading cause of dementia marked by the accumulation and aggregation of amyloid-β peptide and phosphorylated tau (p-tau) protein and concomitant dementia, neuron loss and brain atrophy. AD is the most prevalent neurodegenerative brain disorder with sporadic etiology, except for a small fraction of cases with familial inheritance where familial forms of AD are correlated to mutations in three functionally related genes: the amyloid-β protein precursor and presenilins 1 and 2, two key γ-secretase components. The common clinical features of AD are memory impairment that interrupts daily life, difficulty in accomplishing usual tasks, confusion with time or place, trouble understanding visual images and spatial relationships. Age is the most significant risk factor for AD, whereas other risk factors correlated with AD are hypercholesterolemia, hypertension, atherosclerosis, coronary heart disease, smoking, obesity, and diabetes. Despite decades of research, there is no satisfying therapy which will terminate the advancement of AD by acting on the origin of the disease process, whereas currently available therapeutics only provide symptomatic relief but fail to attain a definite cure and prevention. This review also represents the current status of AD in Bangladesh.
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spelling pubmed-61596512018-11-26 Overview and Current Status of Alzheimer’s Disease in Bangladesh Rahman, Md. Rashidur Tajmim, Afsana Ali, Mohammad Sharif, Mostakim J Alzheimers Dis Rep Review Alzheimer’s disease (AD) is a complex neurological disorder with economic, social, and medical burdens which is acknowledged as leading cause of dementia marked by the accumulation and aggregation of amyloid-β peptide and phosphorylated tau (p-tau) protein and concomitant dementia, neuron loss and brain atrophy. AD is the most prevalent neurodegenerative brain disorder with sporadic etiology, except for a small fraction of cases with familial inheritance where familial forms of AD are correlated to mutations in three functionally related genes: the amyloid-β protein precursor and presenilins 1 and 2, two key γ-secretase components. The common clinical features of AD are memory impairment that interrupts daily life, difficulty in accomplishing usual tasks, confusion with time or place, trouble understanding visual images and spatial relationships. Age is the most significant risk factor for AD, whereas other risk factors correlated with AD are hypercholesterolemia, hypertension, atherosclerosis, coronary heart disease, smoking, obesity, and diabetes. Despite decades of research, there is no satisfying therapy which will terminate the advancement of AD by acting on the origin of the disease process, whereas currently available therapeutics only provide symptomatic relief but fail to attain a definite cure and prevention. This review also represents the current status of AD in Bangladesh. IOS Press 2017-07-01 /pmc/articles/PMC6159651/ /pubmed/30480227 http://dx.doi.org/10.3233/ADR-170012 Text en IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Rahman, Md. Rashidur
Tajmim, Afsana
Ali, Mohammad
Sharif, Mostakim
Overview and Current Status of Alzheimer’s Disease in Bangladesh
title Overview and Current Status of Alzheimer’s Disease in Bangladesh
title_full Overview and Current Status of Alzheimer’s Disease in Bangladesh
title_fullStr Overview and Current Status of Alzheimer’s Disease in Bangladesh
title_full_unstemmed Overview and Current Status of Alzheimer’s Disease in Bangladesh
title_short Overview and Current Status of Alzheimer’s Disease in Bangladesh
title_sort overview and current status of alzheimer’s disease in bangladesh
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159651/
https://www.ncbi.nlm.nih.gov/pubmed/30480227
http://dx.doi.org/10.3233/ADR-170012
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