Postacute Delivery of GABA(A) α5 Antagonist Promotes Postischemic Neurological Recovery and Peri-infarct Brain Remodeling

BACKGROUND AND PURPOSE—: Poststroke, neuronal excitability is tonically reduced in peri-infarct tissue via inhibitory influences of extrasynaptic GABA(A) receptors. We hypothesized that GABA(A) α5 blockade by the competitive antagonist S44819 enhances postischemic neurological recovery, brain remode...

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Detalles Bibliográficos
Autores principales: Wang, Ya-chao, Dzyubenko, Egor, Sanchez-Mendoza, Eduardo H., Sardari, Maryam, Silva de Carvalho, Tayana, Doeppner, Thorsten R., Kaltwasser, Britta, Machado, Patricia, Kleinschnitz, Christoph, Bassetti, Claudio L., Hermann, Dirk M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Original Contributions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159671/
https://www.ncbi.nlm.nih.gov/pubmed/30355106
http://dx.doi.org/10.1161/STROKEAHA.118.021378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159671/
https://www.ncbi.nlm.nih.gov/pubmed/30355106
http://dx.doi.org/10.1161/STROKEAHA.118.021378

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