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Predicting Refractive Outcome of Small Incision Lenticule Extraction for Myopia Using Corneal Properties

PURPOSE: To investigate whether preoperative corneal topographic and biomechanical parameters (CTBPs) predict postoperative residual refractive error (RRE). METHODS: We retrospectively included 151 eyes from 151 patients of small-incision lenticule extraction (SMILE) with target RRE of plano and 3-m...

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Autores principales: Wang, Mengyu, Zhang, Yaohua, Wu, Wenjing, Young, Joshua A., Hatch, Kathryn M., Pineda, Roberto, Elze, Tobias, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159733/
https://www.ncbi.nlm.nih.gov/pubmed/30271678
http://dx.doi.org/10.1167/tvst.7.5.11
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author Wang, Mengyu
Zhang, Yaohua
Wu, Wenjing
Young, Joshua A.
Hatch, Kathryn M.
Pineda, Roberto
Elze, Tobias
Wang, Yan
author_facet Wang, Mengyu
Zhang, Yaohua
Wu, Wenjing
Young, Joshua A.
Hatch, Kathryn M.
Pineda, Roberto
Elze, Tobias
Wang, Yan
author_sort Wang, Mengyu
collection PubMed
description PURPOSE: To investigate whether preoperative corneal topographic and biomechanical parameters (CTBPs) predict postoperative residual refractive error (RRE). METHODS: We retrospectively included 151 eyes from 151 patients of small-incision lenticule extraction (SMILE) with target RRE of plano and 3-month measurements of refractive error from Tianjin Eye Hospital. Multivariate linear/logistic regressions were performed to associate age, gender, preoperative refractive error, lenticule thickness, and CTBPs with postoperative RRE/the occurrence of myopic RRE ≤ −0.25 diopter (D). Stepwise regression was used for feature selection. Leave-one-cross-validation was used for model evaluation by the area under the receiver operating characteristic curve (AUC). RESULTS: From linear regression, more myopic RRE was associated with higher preoperative myopia, intraocular pressure (IOP), flattest curvature of anterior cornea (AC), and highest concavity deformation (HCD), and was associated with lower anterior elevation, anterior asphericity, steepest curvature of AC, and second applanation velocity. The occurrence of ≤ −0.25 D RRE was associated with higher myopia, IOP, posterior elevation and asphericity, flattest curvature of AC, first applanation velocity and HCD, and was associated with lower first applanation stiffness parameter, central corneal thickness, anterior elevation and asphericity, steepest curvature of AC, and second applanation velocity as well as thinner lenticule thickness. Compared to the baseline model using age, gender, and preoperative refractive error, adding CTBPs significantly (P < 0.001) improved the AUC performance to 0.771 from 0.615. CONCLUSIONS: Postoperative outcomes of SMILE can be predicted by individual CTBPs. TRANSLATIONAL RELEVANCE: Our findings could be used to customize a refractive nomogram based on individual corneal properties improving outcomes and patient satisfaction.
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spelling pubmed-61597332018-09-28 Predicting Refractive Outcome of Small Incision Lenticule Extraction for Myopia Using Corneal Properties Wang, Mengyu Zhang, Yaohua Wu, Wenjing Young, Joshua A. Hatch, Kathryn M. Pineda, Roberto Elze, Tobias Wang, Yan Transl Vis Sci Technol Articles PURPOSE: To investigate whether preoperative corneal topographic and biomechanical parameters (CTBPs) predict postoperative residual refractive error (RRE). METHODS: We retrospectively included 151 eyes from 151 patients of small-incision lenticule extraction (SMILE) with target RRE of plano and 3-month measurements of refractive error from Tianjin Eye Hospital. Multivariate linear/logistic regressions were performed to associate age, gender, preoperative refractive error, lenticule thickness, and CTBPs with postoperative RRE/the occurrence of myopic RRE ≤ −0.25 diopter (D). Stepwise regression was used for feature selection. Leave-one-cross-validation was used for model evaluation by the area under the receiver operating characteristic curve (AUC). RESULTS: From linear regression, more myopic RRE was associated with higher preoperative myopia, intraocular pressure (IOP), flattest curvature of anterior cornea (AC), and highest concavity deformation (HCD), and was associated with lower anterior elevation, anterior asphericity, steepest curvature of AC, and second applanation velocity. The occurrence of ≤ −0.25 D RRE was associated with higher myopia, IOP, posterior elevation and asphericity, flattest curvature of AC, first applanation velocity and HCD, and was associated with lower first applanation stiffness parameter, central corneal thickness, anterior elevation and asphericity, steepest curvature of AC, and second applanation velocity as well as thinner lenticule thickness. Compared to the baseline model using age, gender, and preoperative refractive error, adding CTBPs significantly (P < 0.001) improved the AUC performance to 0.771 from 0.615. CONCLUSIONS: Postoperative outcomes of SMILE can be predicted by individual CTBPs. TRANSLATIONAL RELEVANCE: Our findings could be used to customize a refractive nomogram based on individual corneal properties improving outcomes and patient satisfaction. The Association for Research in Vision and Ophthalmology 2018-09-26 /pmc/articles/PMC6159733/ /pubmed/30271678 http://dx.doi.org/10.1167/tvst.7.5.11 Text en Copyright 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Articles
Wang, Mengyu
Zhang, Yaohua
Wu, Wenjing
Young, Joshua A.
Hatch, Kathryn M.
Pineda, Roberto
Elze, Tobias
Wang, Yan
Predicting Refractive Outcome of Small Incision Lenticule Extraction for Myopia Using Corneal Properties
title Predicting Refractive Outcome of Small Incision Lenticule Extraction for Myopia Using Corneal Properties
title_full Predicting Refractive Outcome of Small Incision Lenticule Extraction for Myopia Using Corneal Properties
title_fullStr Predicting Refractive Outcome of Small Incision Lenticule Extraction for Myopia Using Corneal Properties
title_full_unstemmed Predicting Refractive Outcome of Small Incision Lenticule Extraction for Myopia Using Corneal Properties
title_short Predicting Refractive Outcome of Small Incision Lenticule Extraction for Myopia Using Corneal Properties
title_sort predicting refractive outcome of small incision lenticule extraction for myopia using corneal properties
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159733/
https://www.ncbi.nlm.nih.gov/pubmed/30271678
http://dx.doi.org/10.1167/tvst.7.5.11
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