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Consumer-related factors influencing antidepressant adherence in unipolar depression: a qualitative study

PURPOSE: To explore factors which facilitate and negatively impact adherence, at initiation, implementation and discontinuation phases of adherence to antidepressant medicines. PATIENTS AND METHODS: Semi-structured, face-to-face interviews were conducted with patients suffering from unipolar depress...

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Autores principales: Srimongkon, Pornchanok, Aslani, Parisa, Chen, Timothy F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159805/
https://www.ncbi.nlm.nih.gov/pubmed/30288027
http://dx.doi.org/10.2147/PPA.S160728
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author Srimongkon, Pornchanok
Aslani, Parisa
Chen, Timothy F
author_facet Srimongkon, Pornchanok
Aslani, Parisa
Chen, Timothy F
author_sort Srimongkon, Pornchanok
collection PubMed
description PURPOSE: To explore factors which facilitate and negatively impact adherence, at initiation, implementation and discontinuation phases of adherence to antidepressant medicines. PATIENTS AND METHODS: Semi-structured, face-to-face interviews were conducted with patients suffering from unipolar depression. The digitally audio-recorded and transcribed verbatim were used. Transcripts were thematically content analyzed and data managed using N-Vivo software. RESULTS: Twenty-three interviews were conducted. The predominant factors facilitating initiation of therapy included self-motivation and severity of depression. Factors aiding persistence with therapy included belief in, and effectiveness of, antidepressants. Stigma and fear of adverse events inhibited initiation of therapy, whilst adverse events and ineffectiveness of antidepressants contributed to discontinuation. Patients with strong perceptions of the necessity and few concerns about antidepressants were more likely to adhere to treatment at all phases of adherence. CONCLUSION: Different factors influence medication adherence at the different phases of adherence. These factors were based on individual perceptions about depression and its treatment, and actual experiences of antidepressant treatment. This information should be considered by health care professionals in delivering targeted and tailored interventions to foster adherence. Strategies to address medication non-adherence in unipolar depression patients should consider the phase of adherence and individual perceptions about depression and its treatment, along with previous experiences with treatment for depression.
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spelling pubmed-61598052018-10-04 Consumer-related factors influencing antidepressant adherence in unipolar depression: a qualitative study Srimongkon, Pornchanok Aslani, Parisa Chen, Timothy F Patient Prefer Adherence Original Research PURPOSE: To explore factors which facilitate and negatively impact adherence, at initiation, implementation and discontinuation phases of adherence to antidepressant medicines. PATIENTS AND METHODS: Semi-structured, face-to-face interviews were conducted with patients suffering from unipolar depression. The digitally audio-recorded and transcribed verbatim were used. Transcripts were thematically content analyzed and data managed using N-Vivo software. RESULTS: Twenty-three interviews were conducted. The predominant factors facilitating initiation of therapy included self-motivation and severity of depression. Factors aiding persistence with therapy included belief in, and effectiveness of, antidepressants. Stigma and fear of adverse events inhibited initiation of therapy, whilst adverse events and ineffectiveness of antidepressants contributed to discontinuation. Patients with strong perceptions of the necessity and few concerns about antidepressants were more likely to adhere to treatment at all phases of adherence. CONCLUSION: Different factors influence medication adherence at the different phases of adherence. These factors were based on individual perceptions about depression and its treatment, and actual experiences of antidepressant treatment. This information should be considered by health care professionals in delivering targeted and tailored interventions to foster adherence. Strategies to address medication non-adherence in unipolar depression patients should consider the phase of adherence and individual perceptions about depression and its treatment, along with previous experiences with treatment for depression. Dove Medical Press 2018-09-19 /pmc/articles/PMC6159805/ /pubmed/30288027 http://dx.doi.org/10.2147/PPA.S160728 Text en © 2018 Srimongkon et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Srimongkon, Pornchanok
Aslani, Parisa
Chen, Timothy F
Consumer-related factors influencing antidepressant adherence in unipolar depression: a qualitative study
title Consumer-related factors influencing antidepressant adherence in unipolar depression: a qualitative study
title_full Consumer-related factors influencing antidepressant adherence in unipolar depression: a qualitative study
title_fullStr Consumer-related factors influencing antidepressant adherence in unipolar depression: a qualitative study
title_full_unstemmed Consumer-related factors influencing antidepressant adherence in unipolar depression: a qualitative study
title_short Consumer-related factors influencing antidepressant adherence in unipolar depression: a qualitative study
title_sort consumer-related factors influencing antidepressant adherence in unipolar depression: a qualitative study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159805/
https://www.ncbi.nlm.nih.gov/pubmed/30288027
http://dx.doi.org/10.2147/PPA.S160728
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