REVERBa couples the circadian clock to hepatic glucocorticoid action

The glucocorticoid receptor (GR) is a major drug target in inflammatory disease. However, chronic glucocorticoid (GC) treatment leads to disordered energy metabolism, including increased weight gain, adiposity, and hepatosteatosis — all programs modulated by the circadian clock. We demonstrated that...

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Detalles Bibliográficos
Autores principales: Caratti, Giorgio, Iqbal, Mudassar, Hunter, Louise, Kim, Donghwan, Wang, Ping, Vonslow, Ryan M., Begley, Nicola, Tetley, Abigail J., Woodburn, Joanna L., Pariollaud, Marie, Maidstone, Robert, Donaldson, Ian J., Zhang, Zhenguang, Ince, Louise M., Kitchen, Gareth, Baxter, Matthew, Poolman, Toryn M., Daniels, Dion A., Stirling, David R., Brocker, Chad, Gonzalez, Frank, Loudon, Andrew S.I., Bechtold, David A., Rattray, Magnus, Matthews, Laura C., Ray, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160001/
https://www.ncbi.nlm.nih.gov/pubmed/30179226
http://dx.doi.org/10.1172/JCI96138

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