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The association of adverse outcomes in the mother with disease progression in offspring in families with clusters of hepatitis B virus infection and unfavorable prognoses in Northwest China
To investigate the transmission routes of hepatitis B virus (HBV) in families with clusters of infection and unfavorable prognoses and to analyze the prevalence of liver cirrhosis (LC) or hepatocellular carcinoma (HCC) in the offspring of these families. Families with clusters of HBV infection and u...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160018/ https://www.ncbi.nlm.nih.gov/pubmed/30235671 http://dx.doi.org/10.1097/MD.0000000000012266 |
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author | Yang, Yuan Jin, Li Tian, Zhen Guo, Dandan Yao, Naijuan Li, Qian Jiang, Zicheng Yang, Daokun Tang, Xianmei Li, Hongbin He, Yingli Liu, Jinfeng Chen, Tianyan Zhao, Yingren |
author_facet | Yang, Yuan Jin, Li Tian, Zhen Guo, Dandan Yao, Naijuan Li, Qian Jiang, Zicheng Yang, Daokun Tang, Xianmei Li, Hongbin He, Yingli Liu, Jinfeng Chen, Tianyan Zhao, Yingren |
author_sort | Yang, Yuan |
collection | PubMed |
description | To investigate the transmission routes of hepatitis B virus (HBV) in families with clusters of infection and unfavorable prognoses and to analyze the prevalence of liver cirrhosis (LC) or hepatocellular carcinoma (HCC) in the offspring of these families. Families with clusters of HBV infection and unfavorable prognoses were enrolled in the study, and general information and serum samples were collected. The prevalence of LC or HCC was compared in offspring of different genders whose parents were diagnosed with LC or HCC. This analysis comprised 102 probands with 51 siblings, 15 parents, 284 children, and 74 spouses. Interestingly, 88.2% of the siblings and 76.8% of the children of these probands were positive for hepatitis B surface antigen (HBsAg), compared with only 9.5% of the spouses (P < .001). There were 266 nuclear families from 102 clustering families. The prevalence of LC or HCC in sons (44.8%) was higher than that in daughters (8.2%; P < .05) in families with mothers with LC or HCC, but there was no difference in families with fathers with LC or HCC. Moreover, the prevalence of LC or HCC in sons from families with mothers with LC or HCC (44.8%) was higher than in the families with fathers with LC or HCC (21.0%, P = .016). The development of LC or HCC in offspring showed a greater relationship with the adverse outcomes induced by HBV infection in the mother compared with the father, and the prevalence of LC or HCC was much higher in male offspring. |
format | Online Article Text |
id | pubmed-6160018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-61600182018-10-12 The association of adverse outcomes in the mother with disease progression in offspring in families with clusters of hepatitis B virus infection and unfavorable prognoses in Northwest China Yang, Yuan Jin, Li Tian, Zhen Guo, Dandan Yao, Naijuan Li, Qian Jiang, Zicheng Yang, Daokun Tang, Xianmei Li, Hongbin He, Yingli Liu, Jinfeng Chen, Tianyan Zhao, Yingren Medicine (Baltimore) Research Article To investigate the transmission routes of hepatitis B virus (HBV) in families with clusters of infection and unfavorable prognoses and to analyze the prevalence of liver cirrhosis (LC) or hepatocellular carcinoma (HCC) in the offspring of these families. Families with clusters of HBV infection and unfavorable prognoses were enrolled in the study, and general information and serum samples were collected. The prevalence of LC or HCC was compared in offspring of different genders whose parents were diagnosed with LC or HCC. This analysis comprised 102 probands with 51 siblings, 15 parents, 284 children, and 74 spouses. Interestingly, 88.2% of the siblings and 76.8% of the children of these probands were positive for hepatitis B surface antigen (HBsAg), compared with only 9.5% of the spouses (P < .001). There were 266 nuclear families from 102 clustering families. The prevalence of LC or HCC in sons (44.8%) was higher than that in daughters (8.2%; P < .05) in families with mothers with LC or HCC, but there was no difference in families with fathers with LC or HCC. Moreover, the prevalence of LC or HCC in sons from families with mothers with LC or HCC (44.8%) was higher than in the families with fathers with LC or HCC (21.0%, P = .016). The development of LC or HCC in offspring showed a greater relationship with the adverse outcomes induced by HBV infection in the mother compared with the father, and the prevalence of LC or HCC was much higher in male offspring. Wolters Kluwer Health 2018-09-21 /pmc/articles/PMC6160018/ /pubmed/30235671 http://dx.doi.org/10.1097/MD.0000000000012266 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | Research Article Yang, Yuan Jin, Li Tian, Zhen Guo, Dandan Yao, Naijuan Li, Qian Jiang, Zicheng Yang, Daokun Tang, Xianmei Li, Hongbin He, Yingli Liu, Jinfeng Chen, Tianyan Zhao, Yingren The association of adverse outcomes in the mother with disease progression in offspring in families with clusters of hepatitis B virus infection and unfavorable prognoses in Northwest China |
title | The association of adverse outcomes in the mother with disease progression in offspring in families with clusters of hepatitis B virus infection and unfavorable prognoses in Northwest China |
title_full | The association of adverse outcomes in the mother with disease progression in offspring in families with clusters of hepatitis B virus infection and unfavorable prognoses in Northwest China |
title_fullStr | The association of adverse outcomes in the mother with disease progression in offspring in families with clusters of hepatitis B virus infection and unfavorable prognoses in Northwest China |
title_full_unstemmed | The association of adverse outcomes in the mother with disease progression in offspring in families with clusters of hepatitis B virus infection and unfavorable prognoses in Northwest China |
title_short | The association of adverse outcomes in the mother with disease progression in offspring in families with clusters of hepatitis B virus infection and unfavorable prognoses in Northwest China |
title_sort | association of adverse outcomes in the mother with disease progression in offspring in families with clusters of hepatitis b virus infection and unfavorable prognoses in northwest china |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160018/ https://www.ncbi.nlm.nih.gov/pubmed/30235671 http://dx.doi.org/10.1097/MD.0000000000012266 |
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