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Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate
The mechanism of rapid energy supply to the brain, especially to accommodate the heightened metabolic activity of excited states, is not well-understood. We explored the role of glycogen as a fuel source for neuromodulation using the noradrenergic stimulation of glia in a computational model of the...
Autores principales: | Coggan, Jay S., Keller, Daniel, Calì, Corrado, Lehväslaiho, Heikki, Markram, Henry, Schürmann, Felix, Magistretti, Pierre J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160207/ https://www.ncbi.nlm.nih.gov/pubmed/30161133 http://dx.doi.org/10.1371/journal.pcbi.1006392 |
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