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Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones
The threat of viral pandemics demands a comprehensive understanding of evolution at the host–pathogen interface. Here, we show that the accessibility of adaptive mutations in influenza nucleoprotein at fever-like temperatures is mediated by host chaperones. Particularly noteworthy, we observe that t...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160216/ https://www.ncbi.nlm.nih.gov/pubmed/30222731 http://dx.doi.org/10.1371/journal.pbio.3000008 |