Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones

The threat of viral pandemics demands a comprehensive understanding of evolution at the host–pathogen interface. Here, we show that the accessibility of adaptive mutations in influenza nucleoprotein at fever-like temperatures is mediated by host chaperones. Particularly noteworthy, we observe that t...

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Detalles Bibliográficos
Autores principales: Phillips, Angela M., Ponomarenko, Anna I., Chen, Kenny, Ashenberg, Orr, Miao, Jiayuan, McHugh, Sean M., Butty, Vincent L., Whittaker, Charles A., Moore, Christopher L., Bloom, Jesse D., Lin, Yu-Shan, Shoulders, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160216/
https://www.ncbi.nlm.nih.gov/pubmed/30222731
http://dx.doi.org/10.1371/journal.pbio.3000008

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