Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16

CHIP (carboxyl terminus of heat shock 70-interacting protein) has long been recognized as an active member of the cellular protein quality control system given the ability of CHIP to function as both a co-chaperone and ubiquitin ligase. We discovered a genetic disease, now known as spinocerebellar a...

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Detalles Bibliográficos
Autores principales: Shi, Chang-he, Rubel, Carrie, Soss, Sarah E., Sanchez-Hodge, Rebekah, Zhang, Shuo, Madrigal, Sabrina C., Ravi, Saranya, McDonough, Holly, Page, Richard C., Chazin, Walter J., Patterson, Cam, Mao, Cheng-yuan, Willis, Monte S., Luo, Hai-Yang, Li, Yu-sheng, Stevens, Donte A., Tang, Mi-bo, Du, Pan, Wang, Yao-he, Hu, Zheng-wei, Xu, Yu-ming, Schisler, Jonathan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160236/
https://www.ncbi.nlm.nih.gov/pubmed/30222779
http://dx.doi.org/10.1371/journal.pgen.1007664

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