High expression of sonic hedgehog in allergic airway epithelia contributes to goblet cell metaplasia

Sonic hedgehog (SHH) is abundantly expressed and critical for morphogenesis in embryonic lungs, however, SHH expression drops to a much lower level in mice from E17.5 and in humans from the 21st gestational week. We find that SHH expression is robustly up-regulated in the airway epithelia of childre...

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Detalles Bibliográficos
Autores principales: Xu, Chengyun, Zou, Chaochun, Hussain, Musaddique, Shi, Wei, Shao, Yanan, Jiang, Ziyan, Wu, Xiling, Lu, Meiping, Wu, Junsong, Xie, Qiangmin, Ke, Yuehai, Long, Fanxin, Tang, Lanfang, Wu, Ximei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160330/
https://www.ncbi.nlm.nih.gov/pubmed/29867080
http://dx.doi.org/10.1038/s41385-018-0033-4

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