Cargando…

High-resolution NMR studies of antibiotics in cellular membranes

The alarming rise of antimicrobial resistance requires antibiotics with unexploited mechanisms. Ideal templates could be antibiotics that target the peptidoglycan precursor lipid II, known as the bacterial Achilles heel, at an irreplaceable pyrophosphate group. Such antibiotics would kill multidrug-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Medeiros-Silva, João, Jekhmane, Shehrazade, Paioni, Alessandra Lucini, Gawarecka, Katarzyna, Baldus, Marc, Swiezewska, Ewa, Breukink, Eefjan, Weingarth, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160437/ https://www.ncbi.nlm.nih.gov/pubmed/30262913 http://dx.doi.org/10.1038/s41467-018-06314-x

Ejemplares similares

Towards the Native Binding Modes of Antibiotics that Target Lipid II
por: Medeiros‐Silva, João, et al.
Publicado: (2019)

Mode of action of teixobactins in cellular membranes
por: Shukla, Rhythm, et al.
Publicado: (2020)

(1)H‐Detected Solid‐State NMR Studies of Water‐Inaccessible Proteins In Vitro and In Situ
por: Medeiros‐Silva, João, et al.
Publicado: (2016)

Shifts in the selectivity filter dynamics cause modal gating in K(+) channels
por: Jekhmane, Shehrazade, et al.
Publicado: (2019)

Specific Lipid Studies in Complex Membranes by Solid‐State NMR Spectroscopy
por: van Beekveld, Roy A. M., et al.
Publicado: (2022)

Elucidating Self‐Assembling Peptide Aggregation via Morphoscanner: A New Tool for Protein‐Peptide Structural Characterization
por: Saracino, Gloria A. A., et al.
Publicado: (2018)

Design Parameters of Tissue‐Engineering Scaffolds at the Atomic Scale
por: Jekhmane, Shehrazade, et al.
Publicado: (2019)

Brevibacillin 2V Exerts Its Bactericidal Activity via Binding to Lipid II and Permeabilizing Cellular Membranes
por: Zhao, Xinghong, et al.
Publicado: (2021)

The Membrane Steps of Bacterial Cell Wall Synthesis as Antibiotic Targets
por: Liu, Yao, et al.
Publicado: (2016)

DNP‐Supported Solid‐State NMR Spectroscopy of Proteins Inside Mammalian Cells
por: Narasimhan, Siddarth, et al.
Publicado: (2019)

Development of in vitro-grown spheroids as a 3D tumor model system for solid-state NMR spectroscopy
por: Damman, Reinier, et al.
Publicado: (2020)

Brevibacillin 2V, a Novel Antimicrobial Lipopeptide With an Exceptionally Low Hemolytic Activity
por: Zhao, Xinghong, et al.
Publicado: (2021)

Optimizing Exogenous Surfactant as a Pulmonary Delivery Vehicle for Chicken Cathelicidin-2
por: Baer, Brandon, et al.
Publicado: (2020)

In Vivo Assembly of Artificial Metalloenzymes and Application in Whole‐Cell Biocatalysis
por: Chordia, Shreyans, et al.
Publicado: (2021)

Formation of the β-barrel assembly machinery complex in lipid bilayers as seen by solid-state NMR
por: Pinto, Cecilia, et al.
Publicado: (2018)

High-resolution NMR in the native state
por: Baldus, Marc
Publicado: (2017)

Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy
por: Damman, Reinier, et al.
Publicado: (2019)

Solid-state NMR [(13)C,(15)N] resonance assignments of the nucleotide-binding domain of a bacterial cyclic nucleotide-gated channel
por: Cukkemane, Abhishek, et al.
Publicado: (2012)

Bridging the Gap between the Direct and Hydrocarbon Pool Mechanisms of the Methanol‐to‐Hydrocarbons Process
por: Chowdhury, Abhishek Dutta, et al.
Publicado: (2018)

Unraveling the Homologation Reaction Sequence of the Zeolite‐Catalyzed Ethanol‐to‐Hydrocarbons Process
por: Chowdhury, Abhishek Dutta, et al.
Publicado: (2019)

Matrix Effects in a Fluid Catalytic Cracking Catalyst Particle: Influence on Structure, Acidity, and Accessibility
por: Velthoen, Marjolein E. Z., et al.
Publicado: (2020)

An Efficient Labelling Approach to Harness Backbone and Side-Chain Protons in (1)H-Detected Solid-State NMR Spectroscopy
por: Mance, Deni, et al.
Publicado: (2015)

Elucidating Zeolite Channel Geometry–Reaction Intermediate Relationships for the Methanol‐to‐Hydrocarbon Process
por: Fu, Donglong, et al.
Publicado: (2020)

Antibacterial photodynamic therapy: overview of a promising approach to fight antibiotic-resistant bacterial infections
por: Liu, Yao, et al.
Publicado: (2015)

Supramolecular Organization and Functional Implications of K(+) Channel Clusters in Membranes
por: Visscher, Koen M., et al.
Publicado: (2017)

Enhanced Membrane Pore Formation through High-Affinity Targeted Antimicrobial Peptides
por: Arnusch, Christopher J., et al.
Publicado: (2012)

Efficient cellular solid-state NMR of membrane proteins by targeted protein labeling
por: Baker, Lindsay A., et al.
Publicado: (2015)

Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions
por: Mueller, Elizabeth A, et al.
Publicado: (2019)

High-Resolution 3D Structure Determination of Kaliotoxin by Solid-State NMR Spectroscopy
por: Korukottu, Jegannath, et al.
Publicado: (2008)

Prenyl Ammonium Salts – New Carriers for Gene Delivery: A B16-F10 Mouse Melanoma Model
por: Grecka, Emilia, et al.
Publicado: (2016)

Effective usage of cationic derivatives of polyprenols as carriers of DNA vaccines against influenza virus
por: Stachyra, Anna, et al.
Publicado: (2017)

cis‐prenyltransferase 3 and α/β‐hydrolase are new determinants of dolichol accumulation in Arabidopsis
por: Gawarecka, Katarzyna, et al.
Publicado: (2021)

Synthesis of Dolichols in Candida albicans Is Co-Regulated with Elongation of Fatty Acids
por: Janik, Anna, et al.
Publicado: (2021)

Characterization of nucleosome sediments for protein interaction studies by solid-state NMR spectroscopy
por: le Paige, Ulric B., et al.
Publicado: (2021)

Poly-Saturated Dolichols from Filamentous Fungi Modulate Activity of Dolichol-Dependent Glycosyltransferase and Physical Properties of Membranes
por: Gryz, Elżbieta, et al.
Publicado: (2019)

Site-specific functionalization of proteins and their applications to therapeutic antibodies
por: van Vught, Remko, et al.
Publicado: (2014)

Regulation of the Peptidoglycan Polymerase Activity of PBP1b by Antagonist Actions of the Core Divisome Proteins FtsBLQ and FtsN
por: Boes, Adrien, et al.
Publicado: (2019)

Lytic transglycosylase MltG cleaves in nascent peptidoglycan and produces short glycan strands
por: Sassine, Jad, et al.
Publicado: (2021)

High‐Resolution NMR Determination of the Dynamic Structure of Membrane Proteins
por: Jaremko, Mariusz, et al.
Publicado: (2016)

Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins
por: Hernández-Rocamora, Víctor M, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vbssu2rjgonsodgt3p8p8ib2o7