Cargando…

The intracellular signalosome of PD-L1 in cancer cells

Programmed cell death-1 ligand-1 (PD-L1) overexpression in cancer cells accelerates tumor progression. PD-L1 possesses two main pro-oncogenic functions. First, PD-L1 is a strong immunosuppressive molecule that inactivates tumor-specific T cells by binding to the inhibitory receptor PD-1. Second, PD-...

Descripción completa

Detalles Bibliográficos
Autores principales: Escors, David, Gato-Cañas, María, Zuazo, Miren, Arasanz, Hugo, García-Granda, María Jesus, Vera, Ruth, Kochan, Grazyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160488/
https://www.ncbi.nlm.nih.gov/pubmed/30275987
http://dx.doi.org/10.1038/s41392-018-0022-9
_version_ 1783358777318178816
author Escors, David
Gato-Cañas, María
Zuazo, Miren
Arasanz, Hugo
García-Granda, María Jesus
Vera, Ruth
Kochan, Grazyna
author_facet Escors, David
Gato-Cañas, María
Zuazo, Miren
Arasanz, Hugo
García-Granda, María Jesus
Vera, Ruth
Kochan, Grazyna
author_sort Escors, David
collection PubMed
description Programmed cell death-1 ligand-1 (PD-L1) overexpression in cancer cells accelerates tumor progression. PD-L1 possesses two main pro-oncogenic functions. First, PD-L1 is a strong immunosuppressive molecule that inactivates tumor-specific T cells by binding to the inhibitory receptor PD-1. Second, PD-L1 function relies on the delivery of intrinsic intracellular signals that enhance cancer cell survival, regulate stress responses and confer resistance toward pro-apoptotic stimuli, such as interferons. Here, we review the current knowledge on intracellular signal transduction pathways regulated by PD-L1, describe its associated signalosome and discuss potential combinations of targeted therapies against the signalosome with PD-L1/PD-1 blockade therapies.
format Online
Article
Text
id pubmed-6160488
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-61604882018-10-01 The intracellular signalosome of PD-L1 in cancer cells Escors, David Gato-Cañas, María Zuazo, Miren Arasanz, Hugo García-Granda, María Jesus Vera, Ruth Kochan, Grazyna Signal Transduct Target Ther Review Article Programmed cell death-1 ligand-1 (PD-L1) overexpression in cancer cells accelerates tumor progression. PD-L1 possesses two main pro-oncogenic functions. First, PD-L1 is a strong immunosuppressive molecule that inactivates tumor-specific T cells by binding to the inhibitory receptor PD-1. Second, PD-L1 function relies on the delivery of intrinsic intracellular signals that enhance cancer cell survival, regulate stress responses and confer resistance toward pro-apoptotic stimuli, such as interferons. Here, we review the current knowledge on intracellular signal transduction pathways regulated by PD-L1, describe its associated signalosome and discuss potential combinations of targeted therapies against the signalosome with PD-L1/PD-1 blockade therapies. Nature Publishing Group UK 2018-09-28 /pmc/articles/PMC6160488/ /pubmed/30275987 http://dx.doi.org/10.1038/s41392-018-0022-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Escors, David
Gato-Cañas, María
Zuazo, Miren
Arasanz, Hugo
García-Granda, María Jesus
Vera, Ruth
Kochan, Grazyna
The intracellular signalosome of PD-L1 in cancer cells
title The intracellular signalosome of PD-L1 in cancer cells
title_full The intracellular signalosome of PD-L1 in cancer cells
title_fullStr The intracellular signalosome of PD-L1 in cancer cells
title_full_unstemmed The intracellular signalosome of PD-L1 in cancer cells
title_short The intracellular signalosome of PD-L1 in cancer cells
title_sort intracellular signalosome of pd-l1 in cancer cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160488/
https://www.ncbi.nlm.nih.gov/pubmed/30275987
http://dx.doi.org/10.1038/s41392-018-0022-9
work_keys_str_mv AT escorsdavid theintracellularsignalosomeofpdl1incancercells
AT gatocanasmaria theintracellularsignalosomeofpdl1incancercells
AT zuazomiren theintracellularsignalosomeofpdl1incancercells
AT arasanzhugo theintracellularsignalosomeofpdl1incancercells
AT garciagrandamariajesus theintracellularsignalosomeofpdl1incancercells
AT veraruth theintracellularsignalosomeofpdl1incancercells
AT kochangrazyna theintracellularsignalosomeofpdl1incancercells
AT escorsdavid intracellularsignalosomeofpdl1incancercells
AT gatocanasmaria intracellularsignalosomeofpdl1incancercells
AT zuazomiren intracellularsignalosomeofpdl1incancercells
AT arasanzhugo intracellularsignalosomeofpdl1incancercells
AT garciagrandamariajesus intracellularsignalosomeofpdl1incancercells
AT veraruth intracellularsignalosomeofpdl1incancercells
AT kochangrazyna intracellularsignalosomeofpdl1incancercells