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Putative Astroglial Dysfunction in Schizophrenia: A Meta-Analysis of (1)H-MRS Studies of Medial Prefrontal Myo-Inositol

Background: Several lines of evidence support a role for astroglial pathology in schizophrenia. Myo-inositol is particularly abundant in astroglia. Many small sized studies have reported on myo-inositol concentration in schizophrenia, but to date these have not been pooled to estimate a collective e...

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Autores principales: Das, Tushar Kanti, Dey, Avyarthana, Sabesan, Priyadharshini, Javadzadeh, Alborz, Théberge, Jean, Radua, Joaquim, Palaniyappan, Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160540/
https://www.ncbi.nlm.nih.gov/pubmed/30298023
http://dx.doi.org/10.3389/fpsyt.2018.00438
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author Das, Tushar Kanti
Dey, Avyarthana
Sabesan, Priyadharshini
Javadzadeh, Alborz
Théberge, Jean
Radua, Joaquim
Palaniyappan, Lena
author_facet Das, Tushar Kanti
Dey, Avyarthana
Sabesan, Priyadharshini
Javadzadeh, Alborz
Théberge, Jean
Radua, Joaquim
Palaniyappan, Lena
author_sort Das, Tushar Kanti
collection PubMed
description Background: Several lines of evidence support a role for astroglial pathology in schizophrenia. Myo-inositol is particularly abundant in astroglia. Many small sized studies have reported on myo-inositol concentration in schizophrenia, but to date these have not been pooled to estimate a collective effect size. Methods: We reviewed all proton magnetic resonance spectroscopy (1H-MRS) studies reporting myo-inositol values for patients satisfying DSM or ICD based criteria for schizophrenia in comparison to a healthy controls group in the medial prefrontal cortex published until February 2018. A random-effects model was used to calculate the pooled effect size using metafor package. A meta-regression analysis of moderator variables was also undertaken. Results: The literature search identified 19 studies published with a total sample size of 585 controls, 561 patients with schizophrenia. Patients with schizophrenia had significantly reduced medial prefrontal myo-inositol compared to controls (RFX standardized mean difference = 0.19, 95% CI [0.05–0.32], z = 2.72, p = 0.0067; heterogeneity p = 0.09). Studies with more female patients reported more notable schizophrenia-related reduction in myo-inositol (z = 2.53, p = 0.011). Discussion: We report a small, but significant reduction in myo-inositol concentration in the medial prefrontal cortex in schizophrenia. The size of the reported effect indicates that the biological pathways affecting the astroglia are likely to operate only in a subset of patients with schizophrenia. MRS myo-inositol could be a useful tool to stratify and investigate such patients.
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spelling pubmed-61605402018-10-08 Putative Astroglial Dysfunction in Schizophrenia: A Meta-Analysis of (1)H-MRS Studies of Medial Prefrontal Myo-Inositol Das, Tushar Kanti Dey, Avyarthana Sabesan, Priyadharshini Javadzadeh, Alborz Théberge, Jean Radua, Joaquim Palaniyappan, Lena Front Psychiatry Psychiatry Background: Several lines of evidence support a role for astroglial pathology in schizophrenia. Myo-inositol is particularly abundant in astroglia. Many small sized studies have reported on myo-inositol concentration in schizophrenia, but to date these have not been pooled to estimate a collective effect size. Methods: We reviewed all proton magnetic resonance spectroscopy (1H-MRS) studies reporting myo-inositol values for patients satisfying DSM or ICD based criteria for schizophrenia in comparison to a healthy controls group in the medial prefrontal cortex published until February 2018. A random-effects model was used to calculate the pooled effect size using metafor package. A meta-regression analysis of moderator variables was also undertaken. Results: The literature search identified 19 studies published with a total sample size of 585 controls, 561 patients with schizophrenia. Patients with schizophrenia had significantly reduced medial prefrontal myo-inositol compared to controls (RFX standardized mean difference = 0.19, 95% CI [0.05–0.32], z = 2.72, p = 0.0067; heterogeneity p = 0.09). Studies with more female patients reported more notable schizophrenia-related reduction in myo-inositol (z = 2.53, p = 0.011). Discussion: We report a small, but significant reduction in myo-inositol concentration in the medial prefrontal cortex in schizophrenia. The size of the reported effect indicates that the biological pathways affecting the astroglia are likely to operate only in a subset of patients with schizophrenia. MRS myo-inositol could be a useful tool to stratify and investigate such patients. Frontiers Media S.A. 2018-09-21 /pmc/articles/PMC6160540/ /pubmed/30298023 http://dx.doi.org/10.3389/fpsyt.2018.00438 Text en Copyright © 2018 Das, Dey, Sabesan, Javadzadeh, Théberge, Radua and Palaniyappan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Das, Tushar Kanti
Dey, Avyarthana
Sabesan, Priyadharshini
Javadzadeh, Alborz
Théberge, Jean
Radua, Joaquim
Palaniyappan, Lena
Putative Astroglial Dysfunction in Schizophrenia: A Meta-Analysis of (1)H-MRS Studies of Medial Prefrontal Myo-Inositol
title Putative Astroglial Dysfunction in Schizophrenia: A Meta-Analysis of (1)H-MRS Studies of Medial Prefrontal Myo-Inositol
title_full Putative Astroglial Dysfunction in Schizophrenia: A Meta-Analysis of (1)H-MRS Studies of Medial Prefrontal Myo-Inositol
title_fullStr Putative Astroglial Dysfunction in Schizophrenia: A Meta-Analysis of (1)H-MRS Studies of Medial Prefrontal Myo-Inositol
title_full_unstemmed Putative Astroglial Dysfunction in Schizophrenia: A Meta-Analysis of (1)H-MRS Studies of Medial Prefrontal Myo-Inositol
title_short Putative Astroglial Dysfunction in Schizophrenia: A Meta-Analysis of (1)H-MRS Studies of Medial Prefrontal Myo-Inositol
title_sort putative astroglial dysfunction in schizophrenia: a meta-analysis of (1)h-mrs studies of medial prefrontal myo-inositol
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160540/
https://www.ncbi.nlm.nih.gov/pubmed/30298023
http://dx.doi.org/10.3389/fpsyt.2018.00438
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