Prophylactic Treatment With Simvastatin Modulates the Immune Response and Increases Animal Survival Following Lethal Sepsis Infection

Chronic use of statins may have anti-inflammatory action, promoting immunomodulation and survival in patients with sepsis. This study aimed to analyze the effects of pretreatment with simvastatin in lethal sepsis induced by cecal ligation and puncture (CLP). Male Swiss mice received prophylactic tre...

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Detalles Bibliográficos
Autores principales: Braga Filho, Jose A. F., Abreu, Afonso G., Rios, Carlos E. P., Trovão, Liana O., Silva, Dimitri Luz F., Cysne, Dalila N., Nascimento, Johnny R., Fortes, Thiare S., Silva, Lucilene A., Guerra, Rosane N. M., Maciel, Márcia C. G., Serezani, Carlos H., Nascimento, Flávia R. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160584/
https://www.ncbi.nlm.nih.gov/pubmed/30298072
http://dx.doi.org/10.3389/fimmu.2018.02137

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