The Role of KLF(4) in Alzheimer’s Disease

Krüppel-like factor 4 (KLF(4)), a member of the family of zinc-finger transcription factors, is widely expressed in range of tissues that play multiple functions. Emerging evidence suggest KLF(4)’s critical regulatory effect on the neurophysiological and neuropathological processes of Alzheimer’s di...

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Detalles Bibliográficos
Autores principales: Cheng, Ziqian, Zou, Xiaohan, Jin, Yang, Gao, Shuohui, Lv, Jiayin, Li, Bingjin, Cui, Ranji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160590/
https://www.ncbi.nlm.nih.gov/pubmed/30297986
http://dx.doi.org/10.3389/fncel.2018.00325
Descripción
Sumario:Krüppel-like factor 4 (KLF(4)), a member of the family of zinc-finger transcription factors, is widely expressed in range of tissues that play multiple functions. Emerging evidence suggest KLF(4)’s critical regulatory effect on the neurophysiological and neuropathological processes of Alzheimer’s disease (AD), indicating that KLF(4) might be a potential therapeutic target of neurodegenerative diseases. In this review, we will summarize relevant studies and illuminate the regulatory role of KLF(4) in the neuroinflammation, neuronal apoptosis, axon regeneration and iron accumulation to clarify KLF(4)’s status in the pathogenesis of AD.

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