The Role of KLF(4) in Alzheimer’s Disease

Krüppel-like factor 4 (KLF(4)), a member of the family of zinc-finger transcription factors, is widely expressed in range of tissues that play multiple functions. Emerging evidence suggest KLF(4)’s critical regulatory effect on the neurophysiological and neuropathological processes of Alzheimer’s di...

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Autores principales: Cheng, Ziqian, Zou, Xiaohan, Jin, Yang, Gao, Shuohui, Lv, Jiayin, Li, Bingjin, Cui, Ranji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160590/
https://www.ncbi.nlm.nih.gov/pubmed/30297986
http://dx.doi.org/10.3389/fncel.2018.00325
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author Cheng, Ziqian
Zou, Xiaohan
Jin, Yang
Gao, Shuohui
Lv, Jiayin
Li, Bingjin
Cui, Ranji
author_facet Cheng, Ziqian
Zou, Xiaohan
Jin, Yang
Gao, Shuohui
Lv, Jiayin
Li, Bingjin
Cui, Ranji
author_sort Cheng, Ziqian
collection PubMed
description Krüppel-like factor 4 (KLF(4)), a member of the family of zinc-finger transcription factors, is widely expressed in range of tissues that play multiple functions. Emerging evidence suggest KLF(4)’s critical regulatory effect on the neurophysiological and neuropathological processes of Alzheimer’s disease (AD), indicating that KLF(4) might be a potential therapeutic target of neurodegenerative diseases. In this review, we will summarize relevant studies and illuminate the regulatory role of KLF(4) in the neuroinflammation, neuronal apoptosis, axon regeneration and iron accumulation to clarify KLF(4)’s status in the pathogenesis of AD.
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spelling pubmed-61605902018-10-08 The Role of KLF(4) in Alzheimer’s Disease Cheng, Ziqian Zou, Xiaohan Jin, Yang Gao, Shuohui Lv, Jiayin Li, Bingjin Cui, Ranji Front Cell Neurosci Neuroscience Krüppel-like factor 4 (KLF(4)), a member of the family of zinc-finger transcription factors, is widely expressed in range of tissues that play multiple functions. Emerging evidence suggest KLF(4)’s critical regulatory effect on the neurophysiological and neuropathological processes of Alzheimer’s disease (AD), indicating that KLF(4) might be a potential therapeutic target of neurodegenerative diseases. In this review, we will summarize relevant studies and illuminate the regulatory role of KLF(4) in the neuroinflammation, neuronal apoptosis, axon regeneration and iron accumulation to clarify KLF(4)’s status in the pathogenesis of AD. Frontiers Media S.A. 2018-09-21 /pmc/articles/PMC6160590/ /pubmed/30297986 http://dx.doi.org/10.3389/fncel.2018.00325 Text en Copyright © 2018 Cheng, Zou, Jin, Gao, Lv, Li and Cui. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Cheng, Ziqian
Zou, Xiaohan
Jin, Yang
Gao, Shuohui
Lv, Jiayin
Li, Bingjin
Cui, Ranji
The Role of KLF(4) in Alzheimer’s Disease
title The Role of KLF(4) in Alzheimer’s Disease
title_full The Role of KLF(4) in Alzheimer’s Disease
title_fullStr The Role of KLF(4) in Alzheimer’s Disease
title_full_unstemmed The Role of KLF(4) in Alzheimer’s Disease
title_short The Role of KLF(4) in Alzheimer’s Disease
title_sort role of klf(4) in alzheimer’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160590/
https://www.ncbi.nlm.nih.gov/pubmed/30297986
http://dx.doi.org/10.3389/fncel.2018.00325
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