Cargando…

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

INTRODUCTION: Speech impairment in Parkinson's disease (PD) is pervasive, with life‐impacting consequences. Yet, little is known about how functional connections between the basal ganglia and cortex relate to PD speech impairment (PDSI). Whole‐brain resting‐state connectivity analyses of basal...

Descripción completa

Detalles Bibliográficos
Autores principales: Manes, Jordan L., Tjaden, Kris, Parrish, Todd, Simuni, Tanya, Roberts, Angela, Greenlee, Jeremy D., Corcos, Daniel M., Kurani, Ajay S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160640/
https://www.ncbi.nlm.nih.gov/pubmed/30047249
http://dx.doi.org/10.1002/brb3.1073
_version_ 1783358809107857408
author Manes, Jordan L.
Tjaden, Kris
Parrish, Todd
Simuni, Tanya
Roberts, Angela
Greenlee, Jeremy D.
Corcos, Daniel M.
Kurani, Ajay S.
author_facet Manes, Jordan L.
Tjaden, Kris
Parrish, Todd
Simuni, Tanya
Roberts, Angela
Greenlee, Jeremy D.
Corcos, Daniel M.
Kurani, Ajay S.
author_sort Manes, Jordan L.
collection PubMed
description INTRODUCTION: Speech impairment in Parkinson's disease (PD) is pervasive, with life‐impacting consequences. Yet, little is known about how functional connections between the basal ganglia and cortex relate to PD speech impairment (PDSI). Whole‐brain resting‐state connectivity analyses of basal ganglia nuclei can expand the understanding of PDSI pathophysiology. METHODS: Resting‐state data from 89 right‐handed subjects were downloaded from the Parkinson's Progression Markers Initiative database. Subjects included 12 older healthy controls (“OHC”), 42 PD patients without speech impairment (“PDN”), and 35 PD subjects with speech impairment (“PDSI”). Subjects were assigned to PDN and PDSI groups based on the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) Part III speech item scores (“0” vs. “1–4”). Whole‐brain functional connectivity was calculated for four basal ganglia seeds in each hemisphere: putamen, caudate, external globus pallidus (GPe), and internal globus pallidus (GPi). For each seed region, group‐averaged connectivity maps were compared among OHC, PDN, and PDSI groups using a multivariate ANCOVA controlling for the effects of age and sex. Subsequent planned pairwise t‐tests were performed to determine differences between the three groups using a voxel‐wise threshold of p < 0.001 and cluster‐extent threshold of 272 mm(3) (FWE<0.05). RESULTS: In comparison with OHCs, both PDN and PDSI groups demonstrated significant differences in cortical connectivity with bilateral putamen, bilateral GPe, and right caudate. Compared to the PDN group, the PDSI subjects demonstrated significant differences in cortical connectivity with left putamen and left GPi. PDSI subjects had lower connectivity between the left putamen and left superior temporal gyrus compared to PDN. In addition, PDSI subjects had greater connectivity between left GPi and three cortical regions: left dorsal premotor/laryngeal motor cortex, left angular gyrus, and right angular gyrus. CONCLUSIONS: The present findings suggest that speech impairment in PD is associated with altered cortical connectivity with left putamen and left GPi.
format Online
Article
Text
id pubmed-6160640
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-61606402018-10-01 Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease Manes, Jordan L. Tjaden, Kris Parrish, Todd Simuni, Tanya Roberts, Angela Greenlee, Jeremy D. Corcos, Daniel M. Kurani, Ajay S. Brain Behav Original Research INTRODUCTION: Speech impairment in Parkinson's disease (PD) is pervasive, with life‐impacting consequences. Yet, little is known about how functional connections between the basal ganglia and cortex relate to PD speech impairment (PDSI). Whole‐brain resting‐state connectivity analyses of basal ganglia nuclei can expand the understanding of PDSI pathophysiology. METHODS: Resting‐state data from 89 right‐handed subjects were downloaded from the Parkinson's Progression Markers Initiative database. Subjects included 12 older healthy controls (“OHC”), 42 PD patients without speech impairment (“PDN”), and 35 PD subjects with speech impairment (“PDSI”). Subjects were assigned to PDN and PDSI groups based on the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) Part III speech item scores (“0” vs. “1–4”). Whole‐brain functional connectivity was calculated for four basal ganglia seeds in each hemisphere: putamen, caudate, external globus pallidus (GPe), and internal globus pallidus (GPi). For each seed region, group‐averaged connectivity maps were compared among OHC, PDN, and PDSI groups using a multivariate ANCOVA controlling for the effects of age and sex. Subsequent planned pairwise t‐tests were performed to determine differences between the three groups using a voxel‐wise threshold of p < 0.001 and cluster‐extent threshold of 272 mm(3) (FWE<0.05). RESULTS: In comparison with OHCs, both PDN and PDSI groups demonstrated significant differences in cortical connectivity with bilateral putamen, bilateral GPe, and right caudate. Compared to the PDN group, the PDSI subjects demonstrated significant differences in cortical connectivity with left putamen and left GPi. PDSI subjects had lower connectivity between the left putamen and left superior temporal gyrus compared to PDN. In addition, PDSI subjects had greater connectivity between left GPi and three cortical regions: left dorsal premotor/laryngeal motor cortex, left angular gyrus, and right angular gyrus. CONCLUSIONS: The present findings suggest that speech impairment in PD is associated with altered cortical connectivity with left putamen and left GPi. John Wiley and Sons Inc. 2018-07-25 /pmc/articles/PMC6160640/ /pubmed/30047249 http://dx.doi.org/10.1002/brb3.1073 Text en © 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Manes, Jordan L.
Tjaden, Kris
Parrish, Todd
Simuni, Tanya
Roberts, Angela
Greenlee, Jeremy D.
Corcos, Daniel M.
Kurani, Ajay S.
Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease
title Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease
title_full Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease
title_fullStr Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease
title_full_unstemmed Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease
title_short Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease
title_sort altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in parkinson's disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160640/
https://www.ncbi.nlm.nih.gov/pubmed/30047249
http://dx.doi.org/10.1002/brb3.1073
work_keys_str_mv AT manesjordanl alteredrestingstatefunctionalconnectivityoftheputamenandinternalglobuspallidusisrelatedtospeechimpairmentinparkinsonsdisease
AT tjadenkris alteredrestingstatefunctionalconnectivityoftheputamenandinternalglobuspallidusisrelatedtospeechimpairmentinparkinsonsdisease
AT parrishtodd alteredrestingstatefunctionalconnectivityoftheputamenandinternalglobuspallidusisrelatedtospeechimpairmentinparkinsonsdisease
AT simunitanya alteredrestingstatefunctionalconnectivityoftheputamenandinternalglobuspallidusisrelatedtospeechimpairmentinparkinsonsdisease
AT robertsangela alteredrestingstatefunctionalconnectivityoftheputamenandinternalglobuspallidusisrelatedtospeechimpairmentinparkinsonsdisease
AT greenleejeremyd alteredrestingstatefunctionalconnectivityoftheputamenandinternalglobuspallidusisrelatedtospeechimpairmentinparkinsonsdisease
AT corcosdanielm alteredrestingstatefunctionalconnectivityoftheputamenandinternalglobuspallidusisrelatedtospeechimpairmentinparkinsonsdisease
AT kuraniajays alteredrestingstatefunctionalconnectivityoftheputamenandinternalglobuspallidusisrelatedtospeechimpairmentinparkinsonsdisease