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MRI in predicting conversion to multiple sclerosis within 1 year
OBJECTIVES: Most patients diagnosed with multiple sclerosis (MS) present with a clinically isolated syndrome (CIS). We aimed to verify previously reported imaging and clinical findings, and to identify new MRI findings that might serve as prognostic factors for a second clinical episode or a change...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160649/ https://www.ncbi.nlm.nih.gov/pubmed/30073779 http://dx.doi.org/10.1002/brb3.1042 |
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author | Eran, Ayelet García, Melissa Malouf, Robair Bosak, Noam Wagner, Raz Ganelin‐Cohen, Ester Artsy, Elinor Shifrin, Alla Rozenberg, Ayal |
author_facet | Eran, Ayelet García, Melissa Malouf, Robair Bosak, Noam Wagner, Raz Ganelin‐Cohen, Ester Artsy, Elinor Shifrin, Alla Rozenberg, Ayal |
author_sort | Eran, Ayelet |
collection | PubMed |
description | OBJECTIVES: Most patients diagnosed with multiple sclerosis (MS) present with a clinically isolated syndrome (CIS). We aimed to verify previously reported imaging and clinical findings, and to identify new MRI findings that might serve as prognostic factors for a second clinical episode or a change in the MRI scan during the first year following a CIS. MATERIALS AND METHODS: We identified from our medical records, 46 individuals who presented with an episode of CIS, which was followed clinically and with imaging studies. A neuroradiologist blinded to the clinical data reviewed the images and recorded the number of lesions, lesion location, and the largest longitudinal diameter of the lesion. RESULTS: One year after the first MRI, 25 (54%) patients had progressed to MS. The clinical presentation of those who were and were not diagnosed with MS was predominantly motor or sensory deficit. Patients with lesions that were temporal, occipital, or perpendicular to the corpus callosum at the first episode were more likely to have recurrence. Individuals with a combination of more than 13 lesions, with maximal lesion length greater than 0.75 cm, and a lesion perpendicular to the corpus callosum, had a 19 times higher chance of conversion MS during the following year. CONCLUSIONS: Assessment of the number of lesions, lesion location, and maximal lesion size can predict the risk to develop another clinical episode or a new lesion/new enhancement in MRI during the year after CIS. For patients with a higher risk of recurrence, we recommend closer follow‐up. |
format | Online Article Text |
id | pubmed-6160649 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61606492018-10-01 MRI in predicting conversion to multiple sclerosis within 1 year Eran, Ayelet García, Melissa Malouf, Robair Bosak, Noam Wagner, Raz Ganelin‐Cohen, Ester Artsy, Elinor Shifrin, Alla Rozenberg, Ayal Brain Behav Original Research OBJECTIVES: Most patients diagnosed with multiple sclerosis (MS) present with a clinically isolated syndrome (CIS). We aimed to verify previously reported imaging and clinical findings, and to identify new MRI findings that might serve as prognostic factors for a second clinical episode or a change in the MRI scan during the first year following a CIS. MATERIALS AND METHODS: We identified from our medical records, 46 individuals who presented with an episode of CIS, which was followed clinically and with imaging studies. A neuroradiologist blinded to the clinical data reviewed the images and recorded the number of lesions, lesion location, and the largest longitudinal diameter of the lesion. RESULTS: One year after the first MRI, 25 (54%) patients had progressed to MS. The clinical presentation of those who were and were not diagnosed with MS was predominantly motor or sensory deficit. Patients with lesions that were temporal, occipital, or perpendicular to the corpus callosum at the first episode were more likely to have recurrence. Individuals with a combination of more than 13 lesions, with maximal lesion length greater than 0.75 cm, and a lesion perpendicular to the corpus callosum, had a 19 times higher chance of conversion MS during the following year. CONCLUSIONS: Assessment of the number of lesions, lesion location, and maximal lesion size can predict the risk to develop another clinical episode or a new lesion/new enhancement in MRI during the year after CIS. For patients with a higher risk of recurrence, we recommend closer follow‐up. John Wiley and Sons Inc. 2018-08-02 /pmc/articles/PMC6160649/ /pubmed/30073779 http://dx.doi.org/10.1002/brb3.1042 Text en © 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Eran, Ayelet García, Melissa Malouf, Robair Bosak, Noam Wagner, Raz Ganelin‐Cohen, Ester Artsy, Elinor Shifrin, Alla Rozenberg, Ayal MRI in predicting conversion to multiple sclerosis within 1 year |
title |
MRI in predicting conversion to multiple sclerosis within 1 year |
title_full |
MRI in predicting conversion to multiple sclerosis within 1 year |
title_fullStr |
MRI in predicting conversion to multiple sclerosis within 1 year |
title_full_unstemmed |
MRI in predicting conversion to multiple sclerosis within 1 year |
title_short |
MRI in predicting conversion to multiple sclerosis within 1 year |
title_sort | mri in predicting conversion to multiple sclerosis within 1 year |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160649/ https://www.ncbi.nlm.nih.gov/pubmed/30073779 http://dx.doi.org/10.1002/brb3.1042 |
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