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MRI in predicting conversion to multiple sclerosis within 1 year

OBJECTIVES: Most patients diagnosed with multiple sclerosis (MS) present with a clinically isolated syndrome (CIS). We aimed to verify previously reported imaging and clinical findings, and to identify new MRI findings that might serve as prognostic factors for a second clinical episode or a change...

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Autores principales: Eran, Ayelet, García, Melissa, Malouf, Robair, Bosak, Noam, Wagner, Raz, Ganelin‐Cohen, Ester, Artsy, Elinor, Shifrin, Alla, Rozenberg, Ayal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160649/
https://www.ncbi.nlm.nih.gov/pubmed/30073779
http://dx.doi.org/10.1002/brb3.1042
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author Eran, Ayelet
García, Melissa
Malouf, Robair
Bosak, Noam
Wagner, Raz
Ganelin‐Cohen, Ester
Artsy, Elinor
Shifrin, Alla
Rozenberg, Ayal
author_facet Eran, Ayelet
García, Melissa
Malouf, Robair
Bosak, Noam
Wagner, Raz
Ganelin‐Cohen, Ester
Artsy, Elinor
Shifrin, Alla
Rozenberg, Ayal
author_sort Eran, Ayelet
collection PubMed
description OBJECTIVES: Most patients diagnosed with multiple sclerosis (MS) present with a clinically isolated syndrome (CIS). We aimed to verify previously reported imaging and clinical findings, and to identify new MRI findings that might serve as prognostic factors for a second clinical episode or a change in the MRI scan during the first year following a CIS. MATERIALS AND METHODS: We identified from our medical records, 46 individuals who presented with an episode of CIS, which was followed clinically and with imaging studies. A neuroradiologist blinded to the clinical data reviewed the images and recorded the number of lesions, lesion location, and the largest longitudinal diameter of the lesion. RESULTS: One year after the first MRI, 25 (54%) patients had progressed to MS. The clinical presentation of those who were and were not diagnosed with MS was predominantly motor or sensory deficit. Patients with lesions that were temporal, occipital, or perpendicular to the corpus callosum at the first episode were more likely to have recurrence. Individuals with a combination of more than 13 lesions, with maximal lesion length greater than 0.75 cm, and a lesion perpendicular to the corpus callosum, had a 19 times higher chance of conversion MS during the following year. CONCLUSIONS: Assessment of the number of lesions, lesion location, and maximal lesion size can predict the risk to develop another clinical episode or a new lesion/new enhancement in MRI during the year after CIS. For patients with a higher risk of recurrence, we recommend closer follow‐up.
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spelling pubmed-61606492018-10-01 MRI in predicting conversion to multiple sclerosis within 1 year Eran, Ayelet García, Melissa Malouf, Robair Bosak, Noam Wagner, Raz Ganelin‐Cohen, Ester Artsy, Elinor Shifrin, Alla Rozenberg, Ayal Brain Behav Original Research OBJECTIVES: Most patients diagnosed with multiple sclerosis (MS) present with a clinically isolated syndrome (CIS). We aimed to verify previously reported imaging and clinical findings, and to identify new MRI findings that might serve as prognostic factors for a second clinical episode or a change in the MRI scan during the first year following a CIS. MATERIALS AND METHODS: We identified from our medical records, 46 individuals who presented with an episode of CIS, which was followed clinically and with imaging studies. A neuroradiologist blinded to the clinical data reviewed the images and recorded the number of lesions, lesion location, and the largest longitudinal diameter of the lesion. RESULTS: One year after the first MRI, 25 (54%) patients had progressed to MS. The clinical presentation of those who were and were not diagnosed with MS was predominantly motor or sensory deficit. Patients with lesions that were temporal, occipital, or perpendicular to the corpus callosum at the first episode were more likely to have recurrence. Individuals with a combination of more than 13 lesions, with maximal lesion length greater than 0.75 cm, and a lesion perpendicular to the corpus callosum, had a 19 times higher chance of conversion MS during the following year. CONCLUSIONS: Assessment of the number of lesions, lesion location, and maximal lesion size can predict the risk to develop another clinical episode or a new lesion/new enhancement in MRI during the year after CIS. For patients with a higher risk of recurrence, we recommend closer follow‐up. John Wiley and Sons Inc. 2018-08-02 /pmc/articles/PMC6160649/ /pubmed/30073779 http://dx.doi.org/10.1002/brb3.1042 Text en © 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Eran, Ayelet
García, Melissa
Malouf, Robair
Bosak, Noam
Wagner, Raz
Ganelin‐Cohen, Ester
Artsy, Elinor
Shifrin, Alla
Rozenberg, Ayal
MRI in predicting conversion to multiple sclerosis within 1 year
title MRI in predicting conversion to multiple sclerosis within 1 year
title_full MRI in predicting conversion to multiple sclerosis within 1 year
title_fullStr MRI in predicting conversion to multiple sclerosis within 1 year
title_full_unstemmed MRI in predicting conversion to multiple sclerosis within 1 year
title_short MRI in predicting conversion to multiple sclerosis within 1 year
title_sort mri in predicting conversion to multiple sclerosis within 1 year
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160649/
https://www.ncbi.nlm.nih.gov/pubmed/30073779
http://dx.doi.org/10.1002/brb3.1042
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