A Single-Chain-Based Hexavalent CD27 Agonist Enhances T Cell Activation and Induces Anti-Tumor Immunity

Tumor necrosis factor receptor superfamily member 7 (TNFRSF7, CD27), expressed primarily by T cells, and its ligand CD27L (TNFSF7, CD70) provide co-stimulatory signals that boost T cell activation, differentiation, and survival. Agonistic stimulation of CD27 is therefore a promising therapeutic conc...

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Detalles Bibliográficos
Autores principales: Thiemann, Meinolf, Richards, David M., Heinonen, Karl, Kluge, Michael, Marschall, Viola, Merz, Christian, Redondo Müller, Mauricio, Schnyder, Tim, Sefrin, Julian P., Sykora, Jaromir, Fricke, Harald, Gieffers, Christian, Hill, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160747/
https://www.ncbi.nlm.nih.gov/pubmed/30298117
http://dx.doi.org/10.3389/fonc.2018.00387

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