Comparative evaluation of the efficacy of commercial and prototype PRRS subunit vaccines against an HP-PRRSV challenge

The objective of this study was to compare the efficacy of a commercial porcine reproductive and respiratory syndrome (PRRS) subunit vaccine and a prototype PRRS II subunit vaccine against a highly pathogenic PRRS virus (HP-PRRSV) in pigs. Both vaccines were administered intramuscularly in 2 doses a...

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Autores principales: DUY, Do Tien, KIM, Hanjin, JEONG, Jiwoon, PARK, Kee Hwan, YANG, Siyeon, OH, Taehwan, KIM, Seeun, KANG, Ikjae, CHAE, Chanhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2018
Materias:
Virology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160886/
https://www.ncbi.nlm.nih.gov/pubmed/30022776
http://dx.doi.org/10.1292/jvms.17-0583
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author DUY, Do Tien
KIM, Hanjin
JEONG, Jiwoon
PARK, Kee Hwan
YANG, Siyeon
OH, Taehwan
KIM, Seeun
KANG, Ikjae
CHAE, Chanhee
author_facet DUY, Do Tien
KIM, Hanjin
JEONG, Jiwoon
PARK, Kee Hwan
YANG, Siyeon
OH, Taehwan
KIM, Seeun
KANG, Ikjae
CHAE, Chanhee
author_sort DUY, Do Tien
collection PubMed
description The objective of this study was to compare the efficacy of a commercial porcine reproductive and respiratory syndrome (PRRS) subunit vaccine and a prototype PRRS II subunit vaccine against a highly pathogenic PRRS virus (HP-PRRSV) in pigs. Both vaccines were administered intramuscularly in 2 doses at 21 and 42 days of age, and the pigs were challenged intranasally with HP-PRRSV at 63 days of age. Pigs vaccinated with the prototype PRRS II subunit vaccine had significantly higher anti-PRRSV antibody titers, a greater number of interferon-γ-secreting cells, and a greater reduction in lung lesion scores compared to pigs vaccinated with the commercial PRRS subunit vaccine. Therefore, the commercial PRRS subunit and prototype PRRS II subunit vaccines are efficacious against HP-PRRSV.
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spelling pubmed-61608862018-10-02 Comparative evaluation of the efficacy of commercial and prototype PRRS subunit vaccines against an HP-PRRSV challenge DUY, Do Tien KIM, Hanjin JEONG, Jiwoon PARK, Kee Hwan YANG, Siyeon OH, Taehwan KIM, Seeun KANG, Ikjae CHAE, Chanhee J Vet Med Sci Virology The objective of this study was to compare the efficacy of a commercial porcine reproductive and respiratory syndrome (PRRS) subunit vaccine and a prototype PRRS II subunit vaccine against a highly pathogenic PRRS virus (HP-PRRSV) in pigs. Both vaccines were administered intramuscularly in 2 doses at 21 and 42 days of age, and the pigs were challenged intranasally with HP-PRRSV at 63 days of age. Pigs vaccinated with the prototype PRRS II subunit vaccine had significantly higher anti-PRRSV antibody titers, a greater number of interferon-γ-secreting cells, and a greater reduction in lung lesion scores compared to pigs vaccinated with the commercial PRRS subunit vaccine. Therefore, the commercial PRRS subunit and prototype PRRS II subunit vaccines are efficacious against HP-PRRSV. The Japanese Society of Veterinary Science 2018-07-18 2018-09 /pmc/articles/PMC6160886/ /pubmed/30022776 http://dx.doi.org/10.1292/jvms.17-0583 Text en ©2018 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Virology
DUY, Do Tien
KIM, Hanjin
JEONG, Jiwoon
PARK, Kee Hwan
YANG, Siyeon
OH, Taehwan
KIM, Seeun
KANG, Ikjae
CHAE, Chanhee
Comparative evaluation of the efficacy of commercial and prototype PRRS subunit vaccines against an HP-PRRSV challenge
title Comparative evaluation of the efficacy of commercial and prototype PRRS subunit vaccines against an HP-PRRSV challenge
title_full Comparative evaluation of the efficacy of commercial and prototype PRRS subunit vaccines against an HP-PRRSV challenge
title_fullStr Comparative evaluation of the efficacy of commercial and prototype PRRS subunit vaccines against an HP-PRRSV challenge
title_full_unstemmed Comparative evaluation of the efficacy of commercial and prototype PRRS subunit vaccines against an HP-PRRSV challenge
title_short Comparative evaluation of the efficacy of commercial and prototype PRRS subunit vaccines against an HP-PRRSV challenge
title_sort comparative evaluation of the efficacy of commercial and prototype prrs subunit vaccines against an hp-prrsv challenge
topic Virology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160886/
https://www.ncbi.nlm.nih.gov/pubmed/30022776
http://dx.doi.org/10.1292/jvms.17-0583
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