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Stabilization of the CD81 Large Extracellular Loop with De Novo Disulfide Bonds Improves Its Amenability for Peptide Grafting

Tetraspan proteins are significantly enriched in the membranes of exosomal vesicles (EVs) and their extracellular domains are attractive targets for engineering towards specific antigen recognition units. To enhance the tolerance of a tetraspanin fold to modification, we achieved significant thermal...

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Detalles Bibliográficos
Autores principales:	Vogt, Stefan, Stadlmayr, Gerhard, Stadlbauer, Katharina, Sádio, Flávio, Andorfer, Peter, Grillari, Johannes, Rüker, Florian, Wozniak-Knopp, Gordana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160918/ https://www.ncbi.nlm.nih.gov/pubmed/30150531 http://dx.doi.org/10.3390/pharmaceutics10030138

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