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Young Adults in Endemic Areas: An Untreated Group in Need of School-Based Preventive Chemotherapy for Schistosomiasis Control and Elimination

Parasitologic surveys of young adults in college and university settings are not commonly done, even in areas known to be endemic for schistosomiasis and soil-transmitted helminths. We have done a survey of 291 students and staff at the Kisumu National Polytechnic in Kisumu, Kenya, using the stool m...

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Autores principales: Korir, Harrison K., Riner, Diana K., Kavere, Emmy, Omondi, Amos, Landry, Jasmine, Kittur, Nupur, Ndombi, Eric M., Ondigo, Bartholomew N., Secor, W. Evan, Karanja, Diana M. S., Colley, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160920/
https://www.ncbi.nlm.nih.gov/pubmed/30274496
http://dx.doi.org/10.3390/tropicalmed3030100
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author Korir, Harrison K.
Riner, Diana K.
Kavere, Emmy
Omondi, Amos
Landry, Jasmine
Kittur, Nupur
Ndombi, Eric M.
Ondigo, Bartholomew N.
Secor, W. Evan
Karanja, Diana M. S.
Colley, Daniel G.
author_facet Korir, Harrison K.
Riner, Diana K.
Kavere, Emmy
Omondi, Amos
Landry, Jasmine
Kittur, Nupur
Ndombi, Eric M.
Ondigo, Bartholomew N.
Secor, W. Evan
Karanja, Diana M. S.
Colley, Daniel G.
author_sort Korir, Harrison K.
collection PubMed
description Parasitologic surveys of young adults in college and university settings are not commonly done, even in areas known to be endemic for schistosomiasis and soil-transmitted helminths. We have done a survey of 291 students and staff at the Kisumu National Polytechnic in Kisumu, Kenya, using the stool microscopy Kato-Katz (KK) method and the urine point-of-care circulating cathodic antigen (POC-CCA) test. Based on three stools/two KK slides each, in the 208 participants for whom three consecutive stools were obtained, Schistosoma mansoni prevalence was 17.8%. When all 291 individuals were analyzed based on the first stool, as done by the national neglected tropical disease (NTD) program, and one urine POC-CCA assay (n = 276), the prevalence was 13.7% by KK and 23.2% by POC-CCA. Based on three stools, 2.5% of 208 participants had heavy S. mansoni infections (≥400 eggs/gram feces), with heavy S. mansoni infections making up 13.5% of the S. mansoni cases. The prevalence of the soil-transmitted helminths (STH: Ascaris lumbricoides, Trichuris trichiura and hookworm) by three stools was 1.4%, 3.1%, and 4.1%, respectively, and by the first stool was 1.4%, 2.4% and 1.4%, respectively. This prevalence and intensity of infection with S. mansoni in a college setting warrants mass drug administration with praziquantel. This population of young adults is ‘in school’ and is both approachable and worthy of inclusion in national schistosomiasis control and elimination programs.
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spelling pubmed-61609202018-10-01 Young Adults in Endemic Areas: An Untreated Group in Need of School-Based Preventive Chemotherapy for Schistosomiasis Control and Elimination Korir, Harrison K. Riner, Diana K. Kavere, Emmy Omondi, Amos Landry, Jasmine Kittur, Nupur Ndombi, Eric M. Ondigo, Bartholomew N. Secor, W. Evan Karanja, Diana M. S. Colley, Daniel G. Trop Med Infect Dis Article Parasitologic surveys of young adults in college and university settings are not commonly done, even in areas known to be endemic for schistosomiasis and soil-transmitted helminths. We have done a survey of 291 students and staff at the Kisumu National Polytechnic in Kisumu, Kenya, using the stool microscopy Kato-Katz (KK) method and the urine point-of-care circulating cathodic antigen (POC-CCA) test. Based on three stools/two KK slides each, in the 208 participants for whom three consecutive stools were obtained, Schistosoma mansoni prevalence was 17.8%. When all 291 individuals were analyzed based on the first stool, as done by the national neglected tropical disease (NTD) program, and one urine POC-CCA assay (n = 276), the prevalence was 13.7% by KK and 23.2% by POC-CCA. Based on three stools, 2.5% of 208 participants had heavy S. mansoni infections (≥400 eggs/gram feces), with heavy S. mansoni infections making up 13.5% of the S. mansoni cases. The prevalence of the soil-transmitted helminths (STH: Ascaris lumbricoides, Trichuris trichiura and hookworm) by three stools was 1.4%, 3.1%, and 4.1%, respectively, and by the first stool was 1.4%, 2.4% and 1.4%, respectively. This prevalence and intensity of infection with S. mansoni in a college setting warrants mass drug administration with praziquantel. This population of young adults is ‘in school’ and is both approachable and worthy of inclusion in national schistosomiasis control and elimination programs. MDPI 2018-09-05 /pmc/articles/PMC6160920/ /pubmed/30274496 http://dx.doi.org/10.3390/tropicalmed3030100 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Korir, Harrison K.
Riner, Diana K.
Kavere, Emmy
Omondi, Amos
Landry, Jasmine
Kittur, Nupur
Ndombi, Eric M.
Ondigo, Bartholomew N.
Secor, W. Evan
Karanja, Diana M. S.
Colley, Daniel G.
Young Adults in Endemic Areas: An Untreated Group in Need of School-Based Preventive Chemotherapy for Schistosomiasis Control and Elimination
title Young Adults in Endemic Areas: An Untreated Group in Need of School-Based Preventive Chemotherapy for Schistosomiasis Control and Elimination
title_full Young Adults in Endemic Areas: An Untreated Group in Need of School-Based Preventive Chemotherapy for Schistosomiasis Control and Elimination
title_fullStr Young Adults in Endemic Areas: An Untreated Group in Need of School-Based Preventive Chemotherapy for Schistosomiasis Control and Elimination
title_full_unstemmed Young Adults in Endemic Areas: An Untreated Group in Need of School-Based Preventive Chemotherapy for Schistosomiasis Control and Elimination
title_short Young Adults in Endemic Areas: An Untreated Group in Need of School-Based Preventive Chemotherapy for Schistosomiasis Control and Elimination
title_sort young adults in endemic areas: an untreated group in need of school-based preventive chemotherapy for schistosomiasis control and elimination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160920/
https://www.ncbi.nlm.nih.gov/pubmed/30274496
http://dx.doi.org/10.3390/tropicalmed3030100
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