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Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry

A rapid and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of organic anion transporting polypeptide 1B1 (OATP1B1) and cytochrome P450 (P450) probe substrates and their phase I metabolites in human plasma was developed. The OATP1B1 (pita...

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Detalles Bibliográficos
Autores principales:	Heo, Jae-Kyung, Kim, Hyun-Ji, Lee, Ga-Hyun, Ohk, Boram, Lee, Sangkyu, Song, Kyung-Sik, Song, Im Sook, Liu, Kwang-Hyeon, Yoon, Young-Ran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160928/ https://www.ncbi.nlm.nih.gov/pubmed/30004443 http://dx.doi.org/10.3390/pharmaceutics10030079

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