A Novel Protocol Using Small-Scale Spray-Drying for the Efficient Screening of Solid Dispersions in Early Drug Development and Formulation, as a Straight Pathway from Screening to Manufacturing Stages

This work describes a novel screening strategy that implements small-scale spray-drying in early development of binary amorphous solid dispersions (ASDs). The proposed methodology consists of a three-stage decision protocol in which small batches (20–100 mg) of spray-dried solid dispersions (SDSDs)...

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Detalles Bibliográficos
Autores principales: Ousset, Aymeric, Chirico, Rosanna, Robin, Florent, Schubert, Martin Alexander, Somville, Pascal, Dodou, Kalliopi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160943/
https://www.ncbi.nlm.nih.gov/pubmed/30150516
http://dx.doi.org/10.3390/ph11030081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160943/
https://www.ncbi.nlm.nih.gov/pubmed/30150516
http://dx.doi.org/10.3390/ph11030081

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