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Targeted Molecular Imaging Using Aptamers in Cancer
Imaging is not only seeing, but also believing. For targeted imaging modalities, nucleic acid aptamers have features such as superior recognition of structural epitopes and quick uptake in target cells. This explains the emergence of an evolved new class of aptamers into a wide spectrum of imaging a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160950/ https://www.ncbi.nlm.nih.gov/pubmed/30029472 http://dx.doi.org/10.3390/ph11030071 |
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author | Yoon, Sorah Rossi, John J. |
author_facet | Yoon, Sorah Rossi, John J. |
author_sort | Yoon, Sorah |
collection | PubMed |
description | Imaging is not only seeing, but also believing. For targeted imaging modalities, nucleic acid aptamers have features such as superior recognition of structural epitopes and quick uptake in target cells. This explains the emergence of an evolved new class of aptamers into a wide spectrum of imaging applications over the last decade. Genetically encoded biosensors tagged with fluorescent RNA aptamers have been developed as intracellular imaging tools to understand cellular signaling and physiology in live cells. Cancer-specific aptamers labeled with fluorescence have been used for assessment of clinical tissue specimens. Aptamers conjugated with gold nanoparticles have been employed to develop innovative mass spectrometry tissue imaging. Also, use of chemically conjugated cancer-specific aptamers as probes for non-invasive and high-resolution imaging has been transformative for in vivo imaging in multiple cancers. |
format | Online Article Text |
id | pubmed-6160950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61609502018-10-01 Targeted Molecular Imaging Using Aptamers in Cancer Yoon, Sorah Rossi, John J. Pharmaceuticals (Basel) Review Imaging is not only seeing, but also believing. For targeted imaging modalities, nucleic acid aptamers have features such as superior recognition of structural epitopes and quick uptake in target cells. This explains the emergence of an evolved new class of aptamers into a wide spectrum of imaging applications over the last decade. Genetically encoded biosensors tagged with fluorescent RNA aptamers have been developed as intracellular imaging tools to understand cellular signaling and physiology in live cells. Cancer-specific aptamers labeled with fluorescence have been used for assessment of clinical tissue specimens. Aptamers conjugated with gold nanoparticles have been employed to develop innovative mass spectrometry tissue imaging. Also, use of chemically conjugated cancer-specific aptamers as probes for non-invasive and high-resolution imaging has been transformative for in vivo imaging in multiple cancers. MDPI 2018-07-19 /pmc/articles/PMC6160950/ /pubmed/30029472 http://dx.doi.org/10.3390/ph11030071 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yoon, Sorah Rossi, John J. Targeted Molecular Imaging Using Aptamers in Cancer |
title | Targeted Molecular Imaging Using Aptamers in Cancer |
title_full | Targeted Molecular Imaging Using Aptamers in Cancer |
title_fullStr | Targeted Molecular Imaging Using Aptamers in Cancer |
title_full_unstemmed | Targeted Molecular Imaging Using Aptamers in Cancer |
title_short | Targeted Molecular Imaging Using Aptamers in Cancer |
title_sort | targeted molecular imaging using aptamers in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160950/ https://www.ncbi.nlm.nih.gov/pubmed/30029472 http://dx.doi.org/10.3390/ph11030071 |
work_keys_str_mv | AT yoonsorah targetedmolecularimagingusingaptamersincancer AT rossijohnj targetedmolecularimagingusingaptamersincancer |