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Targeted Molecular Imaging Using Aptamers in Cancer

Imaging is not only seeing, but also believing. For targeted imaging modalities, nucleic acid aptamers have features such as superior recognition of structural epitopes and quick uptake in target cells. This explains the emergence of an evolved new class of aptamers into a wide spectrum of imaging a...

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Detalles Bibliográficos
Autores principales: Yoon, Sorah, Rossi, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160950/
https://www.ncbi.nlm.nih.gov/pubmed/30029472
http://dx.doi.org/10.3390/ph11030071
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author Yoon, Sorah
Rossi, John J.
author_facet Yoon, Sorah
Rossi, John J.
author_sort Yoon, Sorah
collection PubMed
description Imaging is not only seeing, but also believing. For targeted imaging modalities, nucleic acid aptamers have features such as superior recognition of structural epitopes and quick uptake in target cells. This explains the emergence of an evolved new class of aptamers into a wide spectrum of imaging applications over the last decade. Genetically encoded biosensors tagged with fluorescent RNA aptamers have been developed as intracellular imaging tools to understand cellular signaling and physiology in live cells. Cancer-specific aptamers labeled with fluorescence have been used for assessment of clinical tissue specimens. Aptamers conjugated with gold nanoparticles have been employed to develop innovative mass spectrometry tissue imaging. Also, use of chemically conjugated cancer-specific aptamers as probes for non-invasive and high-resolution imaging has been transformative for in vivo imaging in multiple cancers.
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spelling pubmed-61609502018-10-01 Targeted Molecular Imaging Using Aptamers in Cancer Yoon, Sorah Rossi, John J. Pharmaceuticals (Basel) Review Imaging is not only seeing, but also believing. For targeted imaging modalities, nucleic acid aptamers have features such as superior recognition of structural epitopes and quick uptake in target cells. This explains the emergence of an evolved new class of aptamers into a wide spectrum of imaging applications over the last decade. Genetically encoded biosensors tagged with fluorescent RNA aptamers have been developed as intracellular imaging tools to understand cellular signaling and physiology in live cells. Cancer-specific aptamers labeled with fluorescence have been used for assessment of clinical tissue specimens. Aptamers conjugated with gold nanoparticles have been employed to develop innovative mass spectrometry tissue imaging. Also, use of chemically conjugated cancer-specific aptamers as probes for non-invasive and high-resolution imaging has been transformative for in vivo imaging in multiple cancers. MDPI 2018-07-19 /pmc/articles/PMC6160950/ /pubmed/30029472 http://dx.doi.org/10.3390/ph11030071 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yoon, Sorah
Rossi, John J.
Targeted Molecular Imaging Using Aptamers in Cancer
title Targeted Molecular Imaging Using Aptamers in Cancer
title_full Targeted Molecular Imaging Using Aptamers in Cancer
title_fullStr Targeted Molecular Imaging Using Aptamers in Cancer
title_full_unstemmed Targeted Molecular Imaging Using Aptamers in Cancer
title_short Targeted Molecular Imaging Using Aptamers in Cancer
title_sort targeted molecular imaging using aptamers in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160950/
https://www.ncbi.nlm.nih.gov/pubmed/30029472
http://dx.doi.org/10.3390/ph11030071
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