Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress

Listeria monocytogenes, a Gram-positive facultative anaerobic bacterium, is becoming a popular vector for cancer immunotherapy. Indeed, multiple vaccines have been developed utilizing modified Listeria as a tool for generating immune responses against a variety of cancers. Moreover, over a dozen cli...

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Detalles Bibliográficos
Autores principales: Flickinger, John C., Rodeck, Ulrich, Snook, Adam E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160973/
https://www.ncbi.nlm.nih.gov/pubmed/30044426
http://dx.doi.org/10.3390/vaccines6030048
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author Flickinger, John C.
Rodeck, Ulrich
Snook, Adam E.
author_facet Flickinger, John C.
Rodeck, Ulrich
Snook, Adam E.
author_sort Flickinger, John C.
collection PubMed
description Listeria monocytogenes, a Gram-positive facultative anaerobic bacterium, is becoming a popular vector for cancer immunotherapy. Indeed, multiple vaccines have been developed utilizing modified Listeria as a tool for generating immune responses against a variety of cancers. Moreover, over a dozen clinical trials testing Listeria cancer vaccines are currently underway, which will help to understand the utility of Listeria vaccines in cancer immunotherapy. This review aims to summarize current views on how Listeria-based vaccines induce potent antitumor immunity and the current state of Listeria-based cancer vaccines in clinical trials.
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spelling pubmed-61609732018-10-01 Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress Flickinger, John C. Rodeck, Ulrich Snook, Adam E. Vaccines (Basel) Review Listeria monocytogenes, a Gram-positive facultative anaerobic bacterium, is becoming a popular vector for cancer immunotherapy. Indeed, multiple vaccines have been developed utilizing modified Listeria as a tool for generating immune responses against a variety of cancers. Moreover, over a dozen clinical trials testing Listeria cancer vaccines are currently underway, which will help to understand the utility of Listeria vaccines in cancer immunotherapy. This review aims to summarize current views on how Listeria-based vaccines induce potent antitumor immunity and the current state of Listeria-based cancer vaccines in clinical trials. MDPI 2018-07-25 /pmc/articles/PMC6160973/ /pubmed/30044426 http://dx.doi.org/10.3390/vaccines6030048 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Flickinger, John C.
Rodeck, Ulrich
Snook, Adam E.
Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress
title Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress
title_full Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress
title_fullStr Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress
title_full_unstemmed Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress
title_short Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress
title_sort listeria monocytogenes as a vector for cancer immunotherapy: current understanding and progress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160973/
https://www.ncbi.nlm.nih.gov/pubmed/30044426
http://dx.doi.org/10.3390/vaccines6030048
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