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Pharmacokinetics, Tissue Distribution and Excretion of a Novel Diuretic (PU-48) in Rats

Methyl 3-amino-6-methoxythieno [2,3-b] quinoline-2-carboxylate (PU-48) is a novel diuretic urea transporter inhibitor. The aim of this study is to investigate the profile of plasma pharmacokinetics, tissue distribution, and excretion by oral dosing of PU-48 in rats. Concentrations of PU-48 within bi...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhi-Yuan, Zhang, Hua, Liu, Dan, Lu, Ying-Yuan, Wang, Xin, Li, Pu, Lou, Ya-Qing, Yang, Bao-Xue, Lou, Ya-Xin, Lu, Chuang, Zhang, Qiang, Zhang, Guo-Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160999/ https://www.ncbi.nlm.nih.gov/pubmed/30096833 http://dx.doi.org/10.3390/pharmaceutics10030124

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