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Melioidosis in the Philippines
The first documented case of melioidosis in the Philippines occurred in 1948. Since then, there have been sporadic reports in the literature about travelers diagnosed with melioidosis after returning from the Philippines. Indigenous cases, however, have been documented rarely, and under-reporting is...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161007/ https://www.ncbi.nlm.nih.gov/pubmed/30274495 http://dx.doi.org/10.3390/tropicalmed3030099 |
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author | San Martin, Peter Franz M. Chua, Joseph C. Bautista, Ralph Louie P. Nailes, Jennifer M. Panaligan, Mario M. Dance, David A. B. |
author_facet | San Martin, Peter Franz M. Chua, Joseph C. Bautista, Ralph Louie P. Nailes, Jennifer M. Panaligan, Mario M. Dance, David A. B. |
author_sort | San Martin, Peter Franz M. |
collection | PubMed |
description | The first documented case of melioidosis in the Philippines occurred in 1948. Since then, there have been sporadic reports in the literature about travelers diagnosed with melioidosis after returning from the Philippines. Indigenous cases, however, have been documented rarely, and under-reporting is highly likely. This review collated all Philippine cases of melioidosis published internationally and locally, as well as unpublished case series and reports from different tertiary hospitals in the Philippines. In total, 25 papers and 41 cases were identified. Among these, 23 were indigenous cases (of which 20 have not been previously reported in the literature). The most common co-morbidity present was diabetes mellitus, and the most common presentations were pulmonary and soft tissue infections. Most of the cases received ceftazidime during the intensive phase, while trimethoprim-sulfamethoxazole was given during the eradication phase. The known mortality rate was 14.6%, while 4.9% of all cases were reported to have had recurrence. The true burden of melioidosis in the country is not well defined. A lack of awareness among clinicians, a dearth of adequate laboratories, and the absence of a surveillance system for the disease are major challenges in determining the magnitude of the problem. |
format | Online Article Text |
id | pubmed-6161007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61610072018-10-01 Melioidosis in the Philippines San Martin, Peter Franz M. Chua, Joseph C. Bautista, Ralph Louie P. Nailes, Jennifer M. Panaligan, Mario M. Dance, David A. B. Trop Med Infect Dis Article The first documented case of melioidosis in the Philippines occurred in 1948. Since then, there have been sporadic reports in the literature about travelers diagnosed with melioidosis after returning from the Philippines. Indigenous cases, however, have been documented rarely, and under-reporting is highly likely. This review collated all Philippine cases of melioidosis published internationally and locally, as well as unpublished case series and reports from different tertiary hospitals in the Philippines. In total, 25 papers and 41 cases were identified. Among these, 23 were indigenous cases (of which 20 have not been previously reported in the literature). The most common co-morbidity present was diabetes mellitus, and the most common presentations were pulmonary and soft tissue infections. Most of the cases received ceftazidime during the intensive phase, while trimethoprim-sulfamethoxazole was given during the eradication phase. The known mortality rate was 14.6%, while 4.9% of all cases were reported to have had recurrence. The true burden of melioidosis in the country is not well defined. A lack of awareness among clinicians, a dearth of adequate laboratories, and the absence of a surveillance system for the disease are major challenges in determining the magnitude of the problem. MDPI 2018-09-05 /pmc/articles/PMC6161007/ /pubmed/30274495 http://dx.doi.org/10.3390/tropicalmed3030099 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article San Martin, Peter Franz M. Chua, Joseph C. Bautista, Ralph Louie P. Nailes, Jennifer M. Panaligan, Mario M. Dance, David A. B. Melioidosis in the Philippines |
title | Melioidosis in the Philippines |
title_full | Melioidosis in the Philippines |
title_fullStr | Melioidosis in the Philippines |
title_full_unstemmed | Melioidosis in the Philippines |
title_short | Melioidosis in the Philippines |
title_sort | melioidosis in the philippines |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161007/ https://www.ncbi.nlm.nih.gov/pubmed/30274495 http://dx.doi.org/10.3390/tropicalmed3030099 |
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