Zika Virus Vaccines: Challenges and Perspectives

Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led...

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Detalles Bibliográficos
Autores principales: das Neves Almeida, Raquel, Racine, Trina, Magalhães, Kelly G., Kobinger, Gary P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161012/
https://www.ncbi.nlm.nih.gov/pubmed/30217027
http://dx.doi.org/10.3390/vaccines6030062
Descripción
Sumario:Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led investigators to develop several candidate vaccines specific to Zika virus. In this review we describe relevant targets for the development of vaccines specific for Zika virus, the development status of various vaccine candidates and their different platforms, as well as their clinical progression.

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