Zika Virus Vaccines: Challenges and Perspectives

Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led...

Descripción completa

Detalles Bibliográficos
Autores principales: das Neves Almeida, Raquel, Racine, Trina, Magalhães, Kelly G., Kobinger, Gary P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161012/
https://www.ncbi.nlm.nih.gov/pubmed/30217027
http://dx.doi.org/10.3390/vaccines6030062
_version_ 1783358896344137728
author das Neves Almeida, Raquel
Racine, Trina
Magalhães, Kelly G.
Kobinger, Gary P.
author_facet das Neves Almeida, Raquel
Racine, Trina
Magalhães, Kelly G.
Kobinger, Gary P.
author_sort das Neves Almeida, Raquel
collection PubMed
description Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led investigators to develop several candidate vaccines specific to Zika virus. In this review we describe relevant targets for the development of vaccines specific for Zika virus, the development status of various vaccine candidates and their different platforms, as well as their clinical progression.
format Online
Article
Text
id pubmed-6161012
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61610122018-10-01 Zika Virus Vaccines: Challenges and Perspectives das Neves Almeida, Raquel Racine, Trina Magalhães, Kelly G. Kobinger, Gary P. Vaccines (Basel) Review Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led investigators to develop several candidate vaccines specific to Zika virus. In this review we describe relevant targets for the development of vaccines specific for Zika virus, the development status of various vaccine candidates and their different platforms, as well as their clinical progression. MDPI 2018-09-13 /pmc/articles/PMC6161012/ /pubmed/30217027 http://dx.doi.org/10.3390/vaccines6030062 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
das Neves Almeida, Raquel
Racine, Trina
Magalhães, Kelly G.
Kobinger, Gary P.
Zika Virus Vaccines: Challenges and Perspectives
title Zika Virus Vaccines: Challenges and Perspectives
title_full Zika Virus Vaccines: Challenges and Perspectives
title_fullStr Zika Virus Vaccines: Challenges and Perspectives
title_full_unstemmed Zika Virus Vaccines: Challenges and Perspectives
title_short Zika Virus Vaccines: Challenges and Perspectives
title_sort zika virus vaccines: challenges and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161012/
https://www.ncbi.nlm.nih.gov/pubmed/30217027
http://dx.doi.org/10.3390/vaccines6030062
work_keys_str_mv AT dasnevesalmeidaraquel zikavirusvaccineschallengesandperspectives
AT racinetrina zikavirusvaccineschallengesandperspectives
AT magalhaeskellyg zikavirusvaccineschallengesandperspectives
AT kobingergaryp zikavirusvaccineschallengesandperspectives

Ejemplares similares