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A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs

Hydrogels are among the most common materials used in drug delivery, as polymeric micelles are too. They, preferentially, load hydrophilic and hydrophobic drugs, respectively. In this paper, we thought to combine the favorable behaviors of both hydrogels and polymeric micelles with the specific aim...

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Autores principales: Mandracchia, Delia, Trapani, Adriana, Perteghella, Sara, Di Franco, Cinzia, Torre, Maria Luisa, Calleri, Enrica, Tripodo, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161022/
https://www.ncbi.nlm.nih.gov/pubmed/30029476
http://dx.doi.org/10.3390/pharmaceutics10030097
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author Mandracchia, Delia
Trapani, Adriana
Perteghella, Sara
Di Franco, Cinzia
Torre, Maria Luisa
Calleri, Enrica
Tripodo, Giuseppe
author_facet Mandracchia, Delia
Trapani, Adriana
Perteghella, Sara
Di Franco, Cinzia
Torre, Maria Luisa
Calleri, Enrica
Tripodo, Giuseppe
author_sort Mandracchia, Delia
collection PubMed
description Hydrogels are among the most common materials used in drug delivery, as polymeric micelles are too. They, preferentially, load hydrophilic and hydrophobic drugs, respectively. In this paper, we thought to combine the favorable behaviors of both hydrogels and polymeric micelles with the specific aim of delivering hydrophilic and hydrophobic drugs for dual delivery in combination therapy, in particular for colon drug delivery. Thus, we developed a hydrogel by UV crosslinking of a methacrylated (MA) amphiphilic derivative from inulin (INU) (as known INU is specifically degraded into the colon) and vitamin E (VITE), called INVITEMA. The methacrylated micelles were physicochemically characterized and subjected to UV irradiation to form what we called the “nanogrids”. The INVITEMA nanogrids were characterized by DSC, SEM, TEM, water uptake and beclomethasone dipropionate (BDP) release. In particular, the release of the hydrophobic drug was specifically assessed to verify that it can spread along the hydrophilic portions and, therefore, effectively released. These systems can open new pharmaceutical applications for known hydrogels or micelle systems, considering that in literature only few examples are present.
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spelling pubmed-61610222018-10-01 A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs Mandracchia, Delia Trapani, Adriana Perteghella, Sara Di Franco, Cinzia Torre, Maria Luisa Calleri, Enrica Tripodo, Giuseppe Pharmaceutics Article Hydrogels are among the most common materials used in drug delivery, as polymeric micelles are too. They, preferentially, load hydrophilic and hydrophobic drugs, respectively. In this paper, we thought to combine the favorable behaviors of both hydrogels and polymeric micelles with the specific aim of delivering hydrophilic and hydrophobic drugs for dual delivery in combination therapy, in particular for colon drug delivery. Thus, we developed a hydrogel by UV crosslinking of a methacrylated (MA) amphiphilic derivative from inulin (INU) (as known INU is specifically degraded into the colon) and vitamin E (VITE), called INVITEMA. The methacrylated micelles were physicochemically characterized and subjected to UV irradiation to form what we called the “nanogrids”. The INVITEMA nanogrids were characterized by DSC, SEM, TEM, water uptake and beclomethasone dipropionate (BDP) release. In particular, the release of the hydrophobic drug was specifically assessed to verify that it can spread along the hydrophilic portions and, therefore, effectively released. These systems can open new pharmaceutical applications for known hydrogels or micelle systems, considering that in literature only few examples are present. MDPI 2018-07-19 /pmc/articles/PMC6161022/ /pubmed/30029476 http://dx.doi.org/10.3390/pharmaceutics10030097 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mandracchia, Delia
Trapani, Adriana
Perteghella, Sara
Di Franco, Cinzia
Torre, Maria Luisa
Calleri, Enrica
Tripodo, Giuseppe
A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs
title A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs
title_full A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs
title_fullStr A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs
title_full_unstemmed A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs
title_short A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs
title_sort micellar-hydrogel nanogrid from a uv crosslinked inulin derivative for the simultaneous delivery of hydrophobic and hydrophilic drugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161022/
https://www.ncbi.nlm.nih.gov/pubmed/30029476
http://dx.doi.org/10.3390/pharmaceutics10030097
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