Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases

The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease dev...

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Autores principales: van der Does, Anne M., Amatngalim, Gimano D., Keijser, Bart, Hiemstra, Pieter S., Villenave, Remi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161034/
https://www.ncbi.nlm.nih.gov/pubmed/30060554
http://dx.doi.org/10.3390/vaccines6030049
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author van der Does, Anne M.
Amatngalim, Gimano D.
Keijser, Bart
Hiemstra, Pieter S.
Villenave, Remi
author_facet van der Does, Anne M.
Amatngalim, Gimano D.
Keijser, Bart
Hiemstra, Pieter S.
Villenave, Remi
author_sort van der Does, Anne M.
collection PubMed
description The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of investigation. Identifying and understanding host-microbiota interactions and factors contributing to these interactions could promote the development of novel therapeutic strategies aimed at restoring host-microbiota homeostasis. In this review, we discuss recent literature on host-microbiota interactions in the respiratory tract, with a specific focus on the influence of endogenous host defence peptides and proteins (HDPs) on the composition of microbiota populations in vivo and explore possible HDPs-related therapeutic approaches targeting microbiota dysbiosis in chronic inflammatory lung diseases.
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spelling pubmed-61610342018-10-01 Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases van der Does, Anne M. Amatngalim, Gimano D. Keijser, Bart Hiemstra, Pieter S. Villenave, Remi Vaccines (Basel) Review The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of investigation. Identifying and understanding host-microbiota interactions and factors contributing to these interactions could promote the development of novel therapeutic strategies aimed at restoring host-microbiota homeostasis. In this review, we discuss recent literature on host-microbiota interactions in the respiratory tract, with a specific focus on the influence of endogenous host defence peptides and proteins (HDPs) on the composition of microbiota populations in vivo and explore possible HDPs-related therapeutic approaches targeting microbiota dysbiosis in chronic inflammatory lung diseases. MDPI 2018-07-28 /pmc/articles/PMC6161034/ /pubmed/30060554 http://dx.doi.org/10.3390/vaccines6030049 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
van der Does, Anne M.
Amatngalim, Gimano D.
Keijser, Bart
Hiemstra, Pieter S.
Villenave, Remi
Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases
title Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases
title_full Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases
title_fullStr Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases
title_full_unstemmed Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases
title_short Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases
title_sort contribution of host defence proteins and peptides to host-microbiota interactions in chronic inflammatory lung diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161034/
https://www.ncbi.nlm.nih.gov/pubmed/30060554
http://dx.doi.org/10.3390/vaccines6030049
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