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Quantitative Analysis of Calcium Phosphate Nanocluster Growth Using Time-of-Flight Medium-Energy-Ion-Scattering Spectroscopy

[Image: see text] One of the remaining challenges in material chemistry is to unveil the quantitative compositional/structural information and thermodynamic nature of inorganic materials especially in the initial nucleation and growth step. In this report, we adopted newly developed time-of-flight m...

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Autores principales: Park, Jimin, Yang, Ki Dong, Kim, Na-Young, Jung, Kang-Won, Le, Viet-Duc, Lim, Hee-Jin, An, Junghyun, Jin, Kyoungsuk, Kim, Yong-Hyun, Nam, Ki Tae, Moon, DaeWon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161037/
https://www.ncbi.nlm.nih.gov/pubmed/30276260
http://dx.doi.org/10.1021/acscentsci.8b00436
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author Park, Jimin
Yang, Ki Dong
Kim, Na-Young
Jung, Kang-Won
Le, Viet-Duc
Lim, Hee-Jin
An, Junghyun
Jin, Kyoungsuk
Kim, Yong-Hyun
Nam, Ki Tae
Moon, DaeWon
author_facet Park, Jimin
Yang, Ki Dong
Kim, Na-Young
Jung, Kang-Won
Le, Viet-Duc
Lim, Hee-Jin
An, Junghyun
Jin, Kyoungsuk
Kim, Yong-Hyun
Nam, Ki Tae
Moon, DaeWon
author_sort Park, Jimin
collection PubMed
description [Image: see text] One of the remaining challenges in material chemistry is to unveil the quantitative compositional/structural information and thermodynamic nature of inorganic materials especially in the initial nucleation and growth step. In this report, we adopted newly developed time-of-flight medium-energy-ion-scattering (TOF-MEIS) spectroscopy to address this challenge and explored heterogeneously grown nanometer-sized calcium phosphate as a model system. With TOF-MEIS, we discovered the existence of calcium-rich nanoclusters (Ca/P ∼ 3) in the presence of the non-collagenous-protein-mimicking passivating ligands. Over the reaction, these clusters progressively changed their compositional ratio toward that of a bulk phase (Ca/P ∼ 1.67) with a concurrent increase in their size to ∼2 nm. First-principles studies suggested that the calcium-rich nanoclusters can be stabilized through specific interactions between the ligands and clusters, emphasizing the important role of template on guiding the chemical and thermodynamic nature of inorganic materials at the nanoscale.
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spelling pubmed-61610372018-10-01 Quantitative Analysis of Calcium Phosphate Nanocluster Growth Using Time-of-Flight Medium-Energy-Ion-Scattering Spectroscopy Park, Jimin Yang, Ki Dong Kim, Na-Young Jung, Kang-Won Le, Viet-Duc Lim, Hee-Jin An, Junghyun Jin, Kyoungsuk Kim, Yong-Hyun Nam, Ki Tae Moon, DaeWon ACS Cent Sci [Image: see text] One of the remaining challenges in material chemistry is to unveil the quantitative compositional/structural information and thermodynamic nature of inorganic materials especially in the initial nucleation and growth step. In this report, we adopted newly developed time-of-flight medium-energy-ion-scattering (TOF-MEIS) spectroscopy to address this challenge and explored heterogeneously grown nanometer-sized calcium phosphate as a model system. With TOF-MEIS, we discovered the existence of calcium-rich nanoclusters (Ca/P ∼ 3) in the presence of the non-collagenous-protein-mimicking passivating ligands. Over the reaction, these clusters progressively changed their compositional ratio toward that of a bulk phase (Ca/P ∼ 1.67) with a concurrent increase in their size to ∼2 nm. First-principles studies suggested that the calcium-rich nanoclusters can be stabilized through specific interactions between the ligands and clusters, emphasizing the important role of template on guiding the chemical and thermodynamic nature of inorganic materials at the nanoscale. American Chemical Society 2018-08-30 2018-09-26 /pmc/articles/PMC6161037/ /pubmed/30276260 http://dx.doi.org/10.1021/acscentsci.8b00436 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Park, Jimin
Yang, Ki Dong
Kim, Na-Young
Jung, Kang-Won
Le, Viet-Duc
Lim, Hee-Jin
An, Junghyun
Jin, Kyoungsuk
Kim, Yong-Hyun
Nam, Ki Tae
Moon, DaeWon
Quantitative Analysis of Calcium Phosphate Nanocluster Growth Using Time-of-Flight Medium-Energy-Ion-Scattering Spectroscopy
title Quantitative Analysis of Calcium Phosphate Nanocluster Growth Using Time-of-Flight Medium-Energy-Ion-Scattering Spectroscopy
title_full Quantitative Analysis of Calcium Phosphate Nanocluster Growth Using Time-of-Flight Medium-Energy-Ion-Scattering Spectroscopy
title_fullStr Quantitative Analysis of Calcium Phosphate Nanocluster Growth Using Time-of-Flight Medium-Energy-Ion-Scattering Spectroscopy
title_full_unstemmed Quantitative Analysis of Calcium Phosphate Nanocluster Growth Using Time-of-Flight Medium-Energy-Ion-Scattering Spectroscopy
title_short Quantitative Analysis of Calcium Phosphate Nanocluster Growth Using Time-of-Flight Medium-Energy-Ion-Scattering Spectroscopy
title_sort quantitative analysis of calcium phosphate nanocluster growth using time-of-flight medium-energy-ion-scattering spectroscopy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161037/
https://www.ncbi.nlm.nih.gov/pubmed/30276260
http://dx.doi.org/10.1021/acscentsci.8b00436
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