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Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System

Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in biomedical fields. Their interaction with the...

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Detalles Bibliográficos
Autores principales: Mohsen, Mona O., Gomes, Ariane C., Vogel, Monique, Bachmann, Martin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161069/
https://www.ncbi.nlm.nih.gov/pubmed/30004398
http://dx.doi.org/10.3390/vaccines6030037
Descripción
Sumario:Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in biomedical fields. Their interaction with the innate immune system is of major importance for the adaptive immune response they induce. The innate immune cells and molecules recognize and interact with VLPs on the basis of two major characteristics: size and surface geometry. This review discusses the interaction of viral capsid-derived VLPs with the innate immune system.