Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System

Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in biomedical fields. Their interaction with the...

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Autores principales: Mohsen, Mona O., Gomes, Ariane C., Vogel, Monique, Bachmann, Martin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161069/
https://www.ncbi.nlm.nih.gov/pubmed/30004398
http://dx.doi.org/10.3390/vaccines6030037
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author Mohsen, Mona O.
Gomes, Ariane C.
Vogel, Monique
Bachmann, Martin F.
author_facet Mohsen, Mona O.
Gomes, Ariane C.
Vogel, Monique
Bachmann, Martin F.
author_sort Mohsen, Mona O.
collection PubMed
description Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in biomedical fields. Their interaction with the innate immune system is of major importance for the adaptive immune response they induce. The innate immune cells and molecules recognize and interact with VLPs on the basis of two major characteristics: size and surface geometry. This review discusses the interaction of viral capsid-derived VLPs with the innate immune system.
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spelling pubmed-61610692018-10-01 Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System Mohsen, Mona O. Gomes, Ariane C. Vogel, Monique Bachmann, Martin F. Vaccines (Basel) Review Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in biomedical fields. Their interaction with the innate immune system is of major importance for the adaptive immune response they induce. The innate immune cells and molecules recognize and interact with VLPs on the basis of two major characteristics: size and surface geometry. This review discusses the interaction of viral capsid-derived VLPs with the innate immune system. MDPI 2018-07-02 /pmc/articles/PMC6161069/ /pubmed/30004398 http://dx.doi.org/10.3390/vaccines6030037 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mohsen, Mona O.
Gomes, Ariane C.
Vogel, Monique
Bachmann, Martin F.
Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System
title Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System
title_full Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System
title_fullStr Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System
title_full_unstemmed Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System
title_short Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System
title_sort interaction of viral capsid-derived virus-like particles (vlps) with the innate immune system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161069/
https://www.ncbi.nlm.nih.gov/pubmed/30004398
http://dx.doi.org/10.3390/vaccines6030037
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